Listvinova S N, Zaslavskaia P L, Dmitrieva S V, Orlova N V
Antibiotiki. 1980 Feb;25(2):88-92.
Act. roseolus rapidly lost its antibiotic activity on passages in liquid media. Degeneration with respect to the antibiotic production property was accompanied by changes in the physiological and morphological characteristics. The culture became low differentiated during the whole developmental cycle. The capacity of the ribosomes for formation of the polysomes and aggregation was decreased or completely lost. The developmental cycle of the culture was shortened because of earlier autolysis and limited formation of the daughter microcolonies. Lincomycin retarded the rate of these changes. The culture preserved its morphological similarity with the initial strain and its viability increased. Therefore, lincomycin promoted some stabilization of the properties of the culture during its passage.
玫红放线菌在液体培养基传代时迅速丧失其抗生素活性。抗生素生产特性的退化伴随着生理和形态特征的变化。该培养物在整个发育周期中变得低分化。核糖体形成多核糖体和聚集的能力降低或完全丧失。由于较早的自溶和子微菌落形成受限，培养物的发育周期缩短。林可霉素减缓了这些变化的速度。该培养物与初始菌株保持形态相似性，其活力增加。因此，林可霉素在传代过程中促进了培养物特性的某种稳定。
