Griaznova N S, Beliavskaia I V, Listvinova S N, Sazykin Iu O, Orlova N V
Antibiotiki. 1980 Apr;25(4):250-6.
The ability of lincomycin, erythromycin and oxytetracycline to affect the synthesis of protein, RNA and DNA in the mycelium of the lincomycin-producing organism Act. roseolus of various ages was studied. The ability of labeled lincomycin to penetrate into the mycelium from the environment was shown and possible presence of the enzymatic systems inactivating lincomycin in the mycelium was studied. Insensitivity of Act. roseolus is due to the protective reactions of the microorganism. One of such reactions involves impermeability of the cell membrane for the antibiotic present in the culture fluid.
研究了林可霉素、红霉素和土霉素对不同年龄的产林可霉素微生物玫瑰放线菌菌丝体中蛋白质、RNA和DNA合成的影响。研究表明了标记的林可霉素从环境中渗透到菌丝体中的能力，并研究了菌丝体中可能存在的使林可霉素失活的酶系统。玫瑰放线菌的不敏感性归因于微生物的保护反应。其中一种反应涉及细胞膜对培养液中存在的抗生素的不透性。
