汽巴克隆蓝F3GA与肝脏乙醇脱氢酶结合的X射线研究。
X-ray studies of the binding of Cibacron blue F3GA to liver alcohol dehydrogenase.
作者信息
Biellmann J F, Samama J P, Bränden C I, Eklund H
出版信息
Eur J Biochem. 1979 Dec;102(1):107-10. doi: 10.1111/j.1432-1033.1979.tb06268.x.
Abstract
The binding of Cibacron F3GA to orthorhombic crystals of liver alcohol dehydrogenase has been studied to 0.37-nm resolution. Similarities in the binding of this dye were found for rings B, C and D with the binding of the coenzyme NAD+. However, ring A of the dye and the nicotinamide ribose part of the coenzyme are quite differently bound to the enzyme.
摘要
已对汽巴克隆F3GA与肝醇脱氢酶正交晶体的结合进行了研究，分辨率达到0.37纳米。发现该染料的B、C和D环与辅酶NAD+的结合存在相似性。然而，该染料的A环和辅酶的烟酰胺核糖部分与酶的结合方式有很大不同。
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