纯化补体成分作用下脂质体中捕获标记物的释放。
Release of trapped marker from liposomes by the action of purified complement components.
作者信息
Haxby J A, Götze O, Müller-Eberhard H J, Kinsky S C
出版信息
Proc Natl Acad Sci U S A. 1969 Sep;64(1):290-5. doi: 10.1073/pnas.64.1.290.
Abstract
Liposomes containing trapped glucose marker were prepared from the chloroform-soluble fraction of sheep erythrocyte membranes. These liposomes release glucose when incubated with rabbit anti-sheep erythrocyte serum and a source of complement. Experiments with purified human complement components show that loss of marker is absolutely dependent on the presence of components 2 and 8. An absolute requirement for component 9 cannot be demonstrated, although it stimulates glucose release from the liposomes. These results establish a parallelism between the response of biological membranes and liposomal membranes to antibody and complement.
摘要
含有捕获葡萄糖标记物的脂质体由绵羊红细胞膜的氯仿可溶部分制备而成。当这些脂质体与兔抗绵羊红细胞血清及补体来源一起孵育时，会释放葡萄糖。用纯化的人补体成分进行的实验表明，标记物的丢失绝对依赖于成分2和8的存在。虽然成分9能刺激脂质体释放葡萄糖，但无法证明其绝对必需性。这些结果确立了生物膜和脂质体膜对抗体及补体反应之间的相似性。
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