新西兰黑鼠的辐射敏感性以及自身免疫性疾病和肿瘤的发展。
Radiation sensitivity of New Zealand black mice and the development of autoimmune disease and neoplasia.
作者信息
Morton J I, Siegel B V
出版信息
Proc Natl Acad Sci U S A. 1971 Jan;68(1):124-6. doi: 10.1073/pnas.68.1.124.
Young New Zealand Black (NZB) mice manifested extremely high resistance to the lethal effects of acute exposures to ionizing radiation, with a dose necessary to kill 50% of the animals within 30 days, LD(50(30)), of 964 roentgens (R) at 30 days of age and of 856 R for 90-day-old mice. In contrast, Coombs' positive 9-month-old NZB mice (with low primary immune response) were highly susceptible (LD(50(30)) = 543 R), possibly because of anemia-stimulated erythropoiesis leading to a depletion of stem cells. The radiation resistance of young NZB mice, combined with previous observations of their immunologic hyper-responsiveness, support the concept that NZB mice possess an unusually large pool of hematopoietic stem cells, an abnormality which may predispose them to the development of autoimmune disease and neoplasia.
年轻的新西兰黑鼠（NZB）对急性电离辐射的致死效应表现出极高的抵抗力，30日龄小鼠在30天内杀死50%动物所需的剂量，即半数致死剂量（LD(50(30))）为964伦琴（R），90日龄小鼠的LD(50(30))为856 R。相比之下，库姆斯试验阳性的9月龄NZB小鼠（初级免疫反应较低）高度敏感（LD(50(30)) = 543 R），这可能是由于贫血刺激的红细胞生成导致干细胞耗竭。年轻NZB小鼠的辐射抗性，结合之前观察到的它们的免疫高反应性，支持了NZB小鼠拥有异常大量造血干细胞池的概念，这种异常可能使它们易患自身免疫性疾病和肿瘤。
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