两条小鼠免疫球蛋白λ链的氨基酸序列。
Amino acid sequences of two mouse immunoglobulin lambda chains.
作者信息
Appella E
出版信息
Proc Natl Acad Sci U S A. 1971 Mar;68(3):590-4. doi: 10.1073/pnas.68.3.590.
Abstract
The amino acid sequences of the lambda chains of two mouse immunoglobulins have been determined. No variations were found between these proteins. The results are compatible with earlier fingerprinting analysis of the two chains, where no differences in the tryptic peptides could be demonstrated. The lack of sequence variations could be the result either of a peculiarly restricted expression of the lambda variable-region genome in the BALB/c myelomas or a small number of germ-line genes involved in the biosynthesis of light chains of the lambda type.
摘要
已测定两种小鼠免疫球蛋白λ链的氨基酸序列。在这些蛋白质之间未发现差异。这些结果与早期对这两条链的指纹分析结果相符，在指纹分析中未发现胰蛋白酶肽段存在差异。序列缺乏变异可能是由于BALB/c骨髓瘤中λ可变区基因组的特殊受限表达，或者是参与λ型轻链生物合成的少数种系基因所致。
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本文引用的文献
1
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Science. 1965 Oct 15;150(3694):361-3. doi: 10.1126/science.150.3694.361.
2
3
Carboxypeptidase B. II. Mode of action on protein substrates and its application to carboxyl terminal group analysis.羧肽酶B。II。对蛋白质底物的作用方式及其在羧基末端基团分析中的应用。
J Biol Chem. 1958 Mar;231(1):393-401.
4
Amino-terminal sequences of two mouse lambda chains.两条小鼠λ链的氨基末端序列。
J Mol Biol. 1968 May 14;33(3):963-6. doi: 10.1016/0022-2836(68)90333-1.
5
Analysis of amino acid phenylthiohydantoins by gas chromatography.气相色谱法分析氨基酸苯硫代乙内酰脲
J Biol Chem. 1969 Oct 25;244(20):5597-607.
6
Lambda Bence Jones proteins of the mouse: chemical and immunological characterization.小鼠的λ本斯·琼斯蛋白：化学与免疫学特性
J Mol Biol. 1967 Jul 28;27(2):391-4. doi: 10.1016/0022-2836(67)90028-9.
7
Mechanism of antibody diversity: germ line basis for variability.抗体多样性的机制：变异性的种系基础。
Science. 1970 Apr 17;168(3929):325-34. doi: 10.1126/science.168.3929.325.
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Hoppe Seylers Z Physiol Chem. 1968 Jul;349(7):945-51.
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