具有抗半抗原活性的小鼠骨髓瘤蛋白轻链的氨基酸序列：第三种轻链类型的证据
Amino acid sequence of the light chain from a mouse myeloma protein with anti-hapten activity: evidence for a third type of light chain.
作者信息
Schulenburg E P, Simms E S, Lynch R G, Bradshaw R A, Eisen H N
出版信息
Proc Natl Acad Sci U S A. 1971 Nov;68(11):2623-6. doi: 10.1073/pnas.68.11.2623.
Abstract
A tentative amino acid sequence has been determined for the light chain of a mouse A-myeloma (MOPC-315) protein with anti-2,4-dinitrophenyl activity. An unusual amino acid sequence in the carboxyl-terminal 104 residues suggests that the chain represents a new class of immunoglobulin light chain. The "variable" segment of this chain (amino-terminal 110 residues) differs at only eight positions from the corresponding segment of the lambda chain of a mouse M-myeloma (MOPC-104) protein with anti-dextran activity.
摘要
已确定一种具有抗2,4 - 二硝基苯基活性的小鼠A - 骨髓瘤（MOPC - 315）蛋白轻链的初步氨基酸序列。羧基末端104个残基中不寻常的氨基酸序列表明该链代表一类新的免疫球蛋白轻链。该链的“可变”区段（氨基末端110个残基）与具有抗葡聚糖活性的小鼠M - 骨髓瘤（MOPC - 104）蛋白的λ链相应区段相比，仅在8个位置上有所不同。
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Amino acid sequence of the light chain from a mouse myeloma protein with anti-hapten activity: evidence for a third type of light chain.具有抗半抗原活性的小鼠骨髓瘤蛋白轻链的氨基酸序列：第三种轻链类型的证据
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Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.巨球蛋白结构：人免疫球蛋白μ和γ重链的同源性
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Amino acid sequence analysis with methyl isothiocyanate. Resolution of the methylthiohydantoins by gas-liquid partition chromatography.用异硫氰酸甲酯进行氨基酸序列分析。通过气液分配色谱法分离甲硫基乙内酰脲。
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Association of allotypic specificities of group a with allotypic specificities A11 and A12 in rabbit immunoglobulin.兔免疫球蛋白中a组同种异型特异性与A11和A12同种异型特异性的关联
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Immunochemical studies of the reaction between a mouse myeloma macroglobulin and dextrans.小鼠骨髓瘤巨球蛋白与葡聚糖之间反应的免疫化学研究。
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Experimental approaches to homogenous antibody populations. Myeloma proteins with antihapten antibody activity.针对同源抗体群体的实验方法。具有抗半抗原抗体活性的骨髓瘤蛋白。
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