Chalmers J P, Baldessarini R J, Wurtman R J
Proc Natl Acad Sci U S A. 1971 Mar;68(3):662-6. doi: 10.1073/pnas.68.3.662.
Rats received intracisternal [(3)H]norepinephrine and, after 5 min, intraperitoneal L-dopa (100 mg/kg); they were killed at intervals during the subsequent 24 hr. Their brains were assayed for norepinephrine, L-dopa, S-adenosylmethionine, and [(3)H]norepinephrine and its metabolites. Rats that received L-dopa had markedly lower brain concentrations of S-adenosylmethionine and of O-methylated metabolites of [(3)H]norepinephrine than controls. An increase (15-40%) in brain norepinephrine content and accelerated turnover of brain norepinephrine was also observed in the animals receiving L-dopa. These changes were all transient, lasting about 1 hr and coinciding with the period when appreciable amounts of L-dopa were detectable in the brain.
给大鼠脑池内注射[³H]去甲肾上腺素，5分钟后腹腔注射左旋多巴（100mg/kg）；在随后的24小时内间隔处死大鼠。检测其脑内的去甲肾上腺素、左旋多巴、S-腺苷甲硫氨酸、[³H]去甲肾上腺素及其代谢产物。接受左旋多巴的大鼠脑内S-腺苷甲硫氨酸和[³H]去甲肾上腺素的O-甲基化代谢产物浓度明显低于对照组。在接受左旋多巴的动物中还观察到脑内去甲肾上腺素含量增加（15%-40%）以及脑内去甲肾上腺素周转加快。这些变化都是短暂的，持续约1小时，与脑内可检测到相当量左旋多巴的时期一致。
