溃疡性结肠炎和克罗恩病中的补体C1q代谢
Clq metabolism in ulcerative colitis and Crohn's disease.
作者信息
Potter B J, Hodgson H J, Mee A S, Jewell D P
出版信息
Gut. 1979 Nov;20(11):1012-9. doi: 10.1136/gut.20.11.1012.
Abstract
The metabolism of pure radioiodine labelled Clq has been observed in five patients with ulcerative colitis, five patients with Crohn's disease, and in five control subjects. Both the fractional catabolic rate and the synthesis rate of Clq were increased in the five patients with Crohn's disease and in four of the five patients with ulcerative colitis. The fifth patient was in remission and had a normal synthesis rate. These results support the hypothesis that complement activation plays a role in the pathogenesis of these disease states and that the increased complement activation is primarily via the classical pathway.
摘要
在五名溃疡性结肠炎患者、五名克罗恩病患者和五名对照受试者中观察了纯放射性碘标记的Clq的代谢情况。五名克罗恩病患者以及五名溃疡性结肠炎患者中的四名，其Clq的分解代谢率分数和合成率均有所升高。第五名患者处于缓解期，其合成率正常。这些结果支持了补体激活在这些疾病状态的发病机制中起作用这一假说，并且补体激活增加主要是通过经典途径。
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