溃疡性结肠炎和克罗恩病中的C3代谢
C3 metabolism in ulcerative colitis and Crohn's disease.
作者信息
Hodgson H J, Potter B J, Jewell D P
出版信息
Clin Exp Immunol. 1977 Jun;28(3):490-5.
Abstract
The metabolism of the third component of complement (C3) has been investigated in four patients with ulcerative colitis, three patients with Crohn's disease and seven control subjects, using radioiodinated C3 prepared from fresh human plasma. Both the fractional catabolic rate and synthesis rate of C3 were increased in the patients with inflammatory bowel disease, although the serum-C3 levels were normal or raised. The results suggest that complement activation may play a role in the pathogenesis of mucosal inflammation in these diseases.
摘要
利用从新鲜人血浆制备的放射性碘化补体3（C3），对4例溃疡性结肠炎患者、3例克罗恩病患者及7名对照者的补体第三成分（C3）代谢情况进行了研究。尽管炎症性肠病患者的血清C3水平正常或升高，但他们的C3分解代谢率和合成率均有所增加。结果表明，补体激活可能在这些疾病的黏膜炎症发病机制中起作用。
相似文献
1
C3 metabolism in ulcerative colitis and Crohn's disease.溃疡性结肠炎和克罗恩病中的C3代谢
Clin Exp Immunol. 1977 Jun;28(3):490-5.
2
Proceedings: Complement in inflammatory bowel disease.
Gut. 1975 Oct;16(10):833-4.
3
Metabolism of the fifth component of complement, and its relation to metabolism of the third component, in patients with complement activation.补体激活患者中补体第五成分的代谢及其与第三成分代谢的关系。
J Clin Invest. 1977 Apr;59(4):704-15. doi: 10.1172/JCI108689.
4
5
Immunohistochemical localization of vascular endothelial growth factor in colonic mucosa of patients with inflammatory bowel disease.血管内皮生长因子在炎症性肠病患者结肠黏膜中的免疫组织化学定位
Hepatogastroenterology. 2002 Jan-Feb;49(43):116-23.
6
Humoral immune system activity in inflammatory bowel disease.炎症性肠病中的体液免疫系统活性。
Scand J Gastroenterol. 1975;10(5):545-9.
7
Hypercatabolism of the third component of complement in patients with primary biliary cirrhosis.原发性胆汁性肝硬化患者补体第三成分的高分解代谢
J Lab Clin Med. 1976 Sep;88(3):427-39.
8
Enhanced local production of complement components in the small intestines of patients with Crohn's disease.克罗恩病患者小肠中补体成分的局部生成增强。
N Engl J Med. 1990 May 10;322(19):1345-9. doi: 10.1056/NEJM199005103221903.
9
Increased expression of VEGF and CD146 in patients with inflammatory bowel disease.炎症性肠病患者中血管内皮生长因子（VEGF）和CD146表达增加。
Dig Liver Dis. 2008 Aug;40(8):673-9. doi: 10.1016/j.dld.2008.02.010. Epub 2008 Apr 18.
10
Kallikrein-kinin system activation in Crohn's disease: differences in intestinal and systemic markers.
Am J Gastroenterol. 2002 Aug;97(8):2026-32. doi: 10.1111/j.1572-0241.2002.05919.x.
引用本文的文献
1
Potential shared pathogenic mechanisms between endometriosis and inflammatory bowel disease indicate a strong initial effect of immune factors.子宫内膜异位症和炎症性肠病之间潜在的共同致病机制表明免疫因素具有强大的初始作用。
Front Immunol. 2024 Apr 3;15:1339647. doi: 10.3389/fimmu.2024.1339647. eCollection 2024.
2
Retinal drusen counts are increased in inflammatory bowel disease, and with longer disease duration, more complications and associated IgA glomerulonephritis.视网膜玻璃膜疣的数量在炎症性肠病中增加，并且随着疾病持续时间的延长，更多的并发症和相关的 IgA 肾小球肾炎。
Sci Rep. 2022 Jul 11;12(1):11744. doi: 10.1038/s41598-022-15232-4.
3
Crohn's Disease Patients in Remission Display an Enhanced Intestinal IgM⁺ B Cell Count in Concert with a Strong Activation of the Intestinal Complement System.缓解期克罗恩病患者肠道 IgM⁺B 细胞计数增加，同时肠道补体系统被强烈激活。
Cells. 2019 Jan 21;8(1):78. doi: 10.3390/cells8010078.
4
High normal serum levels of C3 and C1 inhibitor, two acute-phase proteins belonging to the complement system, occur more frequently in patients with Crohn's disease than ulcerative colitis.属于补体系统的两种急性期蛋白，即血清C3和C1抑制因子水平处于高正常范围，在克罗恩病患者中比溃疡性结肠炎患者中更频繁出现。
Dig Dis Sci. 2003 Jun;48(6):1186-92. doi: 10.1023/a:1023793502456.
5
Multifunctional effects of anticomplementary agent K-76 on carrageenan-induced colitis in the rabbit.
Clin Exp Immunol. 1993 Nov;94(2):348-53. doi: 10.1111/j.1365-2249.1993.tb03456.x.
6
In vitro studies on cellular and humoral chemotaxis in Crohn's disease using the under agarose gel technique.使用琼脂糖凝胶技术对克罗恩病的细胞和体液趋化性进行的体外研究。
Gut. 1981 Jul;22(7):566-70. doi: 10.1136/gut.22.7.566.
7
Circulating immune complexes in Crohn's disease. Their characterization and interrelationship with components of the complement system.克罗恩病中的循环免疫复合物。其特征及与补体系统各成分的相互关系。
Dig Dis Sci. 1982 Feb;27(2):129-38. doi: 10.1007/BF01311706.
8
The in-vivo metabolism of C3 in ankylosing spondylitis.强直性脊柱炎中C3的体内代谢
Ann Rheum Dis. 1982 Feb;41(1):86-9. doi: 10.1136/ard.41.1.86.
9
Subnormal activation of phagocytes by complement in chronic inflammatory bowel disease? Neutrophil chemotaxis to complement split product C5a.慢性炎症性肠病中补体对吞噬细胞的激活不足？中性粒细胞对补体裂解产物C5a的趋化作用。
Gut. 1984 Jul;25(7):737-42. doi: 10.1136/gut.25.7.737.
10
Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease.溃疡性结肠炎和克罗恩病中的补体抑制剂与免疫粘连素
Gut. 1980 Dec;21(12):1030-4. doi: 10.1136/gut.21.12.1030.
本文引用的文献
1
ISOLATION OF BETA IF-GLOBULIN FROM HUMAN SERUM AND ITS CHARACTERIZATION AS THE FIFTH COMPONENT OF COMPLEMENT.从人血清中分离β-免疫球蛋白并将其鉴定为补体的第五成分。
J Exp Med. 1965 Aug 1;122(2):277-98. doi: 10.1084/jem.122.2.277.
2
Persistence of serum complement in sera of patients with ulcerative colitis.溃疡性结肠炎患者血清中补体的持续性
J Lab Clin Med. 1963 Jul;62:24-30.
3
The theory of tracer experiments with 131I-labelled plasma proteins.用131I标记血浆蛋白的示踪实验理论
Phys Med Biol. 1957 Jul;2(1):36-53. doi: 10.1088/0031-9155/2/1/305.
4
Distribution and metabolism of I131 labeled proteins in man.碘-131标记蛋白质在人体中的分布与代谢
Fed Proc. 1957 Jul;16(2):suppl 13-8.
5
Protein chromatography on calcium phosphate columns.在磷酸钙柱上进行蛋白质色谱分析。
Arch Biochem Biophys. 1956 Nov;65(1):132-55. doi: 10.1016/0003-9861(56)90183-7.
6
Behaviour of 14C- and 131I-labelled plasma proteins in the rat.14C和131I标记的血浆蛋白在大鼠体内的行为
Int J Appl Radiat Isot. 1956 Jul;1(1-2):66-84. doi: 10.1016/0020-708x(56)90020-5.
7
Cortisone in ulcerative colitis; final report on a therapeutic trial.可的松治疗溃疡性结肠炎；一项治疗试验的最终报告
Br Med J. 1955 Oct 29;2(4947):1041-8. doi: 10.1136/bmj.2.4947.1041.
8
Short-term measurement of catabolic rates using iodine-labeled plasma protein.使用碘标记血浆蛋白进行分解代谢率的短期测量。
J Clin Invest. 1970 Oct;49(10):1903-11. doi: 10.1172/JCI106409.
9
10
Short-term course and prognosis of Crohn's disease.克罗恩病的短期病程及预后
Gut. 1974 Jun;15(6):435-43. doi: 10.1136/gut.15.6.435.
Zotero 插件