Potter B J, Brown D J, Watson A, Jewell D P
Gut. 1980 Dec;21(12):1030-4. doi: 10.1136/gut.21.12.1030.
The serum concentrations of the complement inactivators C1INH, C3bINA and beta 1H have been determined in patients with ulcerative colitis and Crohn's disease and their correlation with C3 and properdin factor B examined. The incidence of immunoconglutinins (1K) in these patients was investigated. Raised serum concentrations of C1INH and C3bINA have been found in patients with active disease, but no significant alteration was found in serum concentration of beta 1H. An increasing incidence of positive 1K titres was found with increased length of disease history. These results suggest continuing complement activation in these diseases.
已测定溃疡性结肠炎和克罗恩病患者血清中补体灭活剂C1INH、C3bINA和β1H的浓度，并检测了它们与C3和备解素因子B的相关性。对这些患者中免疫粘连素（1K）的发生率进行了研究。发现活动期患者血清中C1INH和C3bINA浓度升高，但β1H血清浓度未发现明显变化。随着病程延长，1K滴度阳性的发生率增加。这些结果提示这些疾病中补体持续激活。
