Brecher S M, van Houte J
Infect Immun. 1979 Dec;26(3):1137-45. doi: 10.1128/iai.26.3.1137-1145.1979.
The colonization of Actinomyces viscosus strain Ny-1R on the molar teeth of conventional and ex-germfree rats of various ages fed either a high-sucrose diet, a high-glucose diet, or laboratory chow was studied. Conventional rats directly after weaning and up to 30 days of age are less susceptible to experimental infection by strain Ny-1R than are older rats regardless of the test diet. The relationship between host age and susceptibility to infection is also demonstrable in ex-germfree rats fed a high-sucose diet. Host factors responsible for the differences in susceptibility were investigated. The results from these studies do not implicate host antibodies, host indigenous flora, or host saliva. In other studies, it was demonstrated that within the mouths of rats, strain Ny-1R preferentially colonizes in the pits and fissures of the molar teeth rather than on the dorsum of the tongue or on the vestibular mucosa. In short-term experiments, it was found that strain Ny-1R attaches to the first molars of 40-day-old conventional rats to a greater extent than it attaches to the first molars of 20-day-old rats. The differences in attachment and subsequent colonization of strain Ny-1R in 20- and 40-day-old rats may be related to the varying amounts of the reduced enamel epithelium and connective tissue present in the fissures of the molar teeth.
研究了粘性放线菌菌株Ny-1R在不同年龄的常规大鼠和无菌大鼠的磨牙上的定殖情况，这些大鼠分别喂食高蔗糖饮食、高葡萄糖饮食或实验室饲料。无论测试饮食如何，刚断奶至30日龄的常规大鼠比年龄较大的大鼠更不易受到菌株Ny-1R的实验性感染。在喂食高蔗糖饮食的无菌大鼠中也可证明宿主年龄与感染易感性之间的关系。研究了导致易感性差异的宿主因素。这些研究结果并未表明宿主抗体、宿主固有菌群或宿主唾液有影响。在其他研究中，已证明在大鼠口腔内，菌株Ny-1R优先定殖于磨牙的窝沟中，而非舌背或前庭粘膜上。在短期实验中，发现菌株Ny-1R附着于40日龄常规大鼠的第一磨牙上的程度大于其附着于20日龄大鼠第一磨牙上的程度。20日龄和40日龄大鼠中菌株Ny-1R附着及随后定殖的差异可能与磨牙窝沟中存在的釉质上皮和结缔组织减少量的变化有关。
