小鼠角膜对铜绿假单胞菌反应的遗传控制
Genetic control of the murine corneal response to Pseudomonas aeruginosa.
作者信息
Berk R S, Leon M A, Hazlett L D
出版信息
Infect Immun. 1979 Dec;26(3):1221-3. doi: 10.1128/iai.26.3.1221-1223.1979.
Abstract
Inbred mouse strains differ in susceptibility to intracorneal challenge with Pseudomonas aeruginosa. Genetic studies indicate that resistance to corneal infection is dominant over susceptibility and is controlled by autosomal genes, at least one of which is located outside of the H-2 locus. On the basis of genetic complementation studies, the susceptible strains BALB/c and C57BL/6 each bear one resistance gene, since the F1 hybrid (BALB/c X C57BL/6) was uniformly resistant to infection.
摘要
近交系小鼠品系对铜绿假单胞菌角膜内攻击的易感性存在差异。遗传学研究表明，对角膜感染的抗性对易感性呈显性，且由常染色体基因控制，其中至少有一个基因位于H-2基因座之外。基于遗传互补研究，易感品系BALB/c和C57BL/6各自携带一个抗性基因，因为F1杂种（BALB/c×C57BL/6）对感染具有一致的抗性。
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本文引用的文献
1
Variation in susceptibility of mouse strains to Leishmania donovani infection.
Trans R Soc Trop Med Hyg. 1972;66(4):527-8.
2
Letter: Genetic control of natural resistance to Leishmania donovani.
Nature. 1974 Jul 26;250(464):353-4. doi: 10.1038/250353a0.
3
Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice.
Nature. 1974 Mar 22;248(446):345-7. doi: 10.1038/248345a0.
4
Histocompatibility-linked immune response genes.
Science. 1972 Jan 21;175(4019):273-9. doi: 10.1126/science.175.4019.273.
5
Genetics of resistance to infection with Salmonella typhimurium in mice.
J Infect Dis. 1976 Jan;133(1):72-8. doi: 10.1093/infdis/133.1.72.
6
Heightened resistance of athymic, nude (nu/nu) mice to experimental Pseudomonas aeruginosa ocular infection.
Infect Immun. 1978 Dec;22(3):926-33. doi: 10.1128/iai.22.3.926-933.1978.
7
Host defenses in experimental scrub typhus: genetics of natural resistance to infection.
Infect Immun. 1978 Feb;19(2):583-8. doi: 10.1128/iai.19.2.583-588.1978.
8
Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis.
Infect Immun. 1978 Mar;19(3):755-62. doi: 10.1128/iai.19.3.755-762.1978.
9
Influence of genetic factors on natural resistance of mice to Pseudomonas aeruginosa.
J Infect Dis. 1979 Apr;139(4):396-400. doi: 10.1093/infdis/139.4.396.
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