Patek P Q, Collins J L, Yogeeswaran G, Dennert G
Int J Cancer. 1979 Nov 15;24(5):624-8. doi: 10.1002/ijc.2910240516.
Data are presented on the effects of retinoic acid (RA) treatment on the in vivo growth of tumors in two mouse strains. Inhibition of tumor growth as a result of systemic RA injection was observed in three out of seven tumor models. Using adult thymectomized, lethally irradiated and fetal liver (A x TFL) reconstituted mice, we found that inhibition of tumor growth is not due to direct toxic effects of RA but rather appears to be the result of stimulation of thymus-dependent immune-mediated effectors to suppress tumor growth. Results suggest that only strongly immunogenic tumors are sensitive to in vivo retinoid inhibition.
本文呈现了维甲酸（RA）治疗对两种小鼠品系肿瘤体内生长的影响的数据。在七个肿瘤模型中的三个模型中，观察到全身性注射RA可抑制肿瘤生长。使用成年胸腺切除、致死性照射并经胎肝（A x TFL）重建的小鼠，我们发现肿瘤生长的抑制并非由于RA的直接毒性作用，而是似乎是由于刺激了胸腺依赖性免疫介导效应器来抑制肿瘤生长。结果表明，只有强免疫原性肿瘤对体内类维生素A抑制敏感。
