Kinsella T D
J Rheumatol. 1979 Nov-Dec;6(6):621-8.
Lymphocyte transformation was studied in 24 patients with ankylosing spondylitis (AS), 21 with rheumatoid arthritis (RA) and 23 control subjects (CS). Enhanced transformation was found in response to phytohemagglutinin (PHA) (p less than 0.01) and human aggregated gamma globulin (p less than 0.025), but not to inulin, for AS patients. Correlation coefficients between the concentrations of each of 8 AS plasma proteins and PHA-induced lymphocyte transformation in autologous plasma showed significance only for C-reactive protein (CRP). However, co-culture experiments with PHA in autologous and allogeneic (AB) plasma, and in CRP-devoid AB serum showed no specific enhancing effect by AS plasma on lymphocyte responses. Although these studied demonstrate that AS is frequently characterized by enhanced in vitro transformation to T lymphocyte dependent mitogens, this response does not appear to be related to the known immunoregulatory properties of CRP.
对24例强直性脊柱炎（AS）患者、21例类风湿性关节炎（RA）患者和23名对照者（CS）进行了淋巴细胞转化研究。AS患者对植物血凝素（PHA）（p<0.01）和人聚合γ球蛋白（p<0.025）有增强的转化反应，但对菊粉无反应。8种AS血浆蛋白各自的浓度与自体血浆中PHA诱导的淋巴细胞转化之间的相关系数仅C反应蛋白（CRP）有显著性。然而，在自体和异体（AB）血浆以及不含CRP的AB血清中与PHA进行共培养实验表明，AS血浆对淋巴细胞反应没有特异性增强作用。尽管这些研究表明AS的特征通常是对T淋巴细胞依赖性有丝分裂原的体外转化增强，但这种反应似乎与CRP已知的免疫调节特性无关。
