Guld J, Rhodes J, Sorkin E, Boyden S
Bull World Health Organ. 1965;33(3):385-94.
Such tuberculin preparations as are currently used for skin testing in human beings are not specific for tuberculous infection. There is, in particular, reason to believe that the kind of low-grade tuberculin sensitivity that is highly prevalent in many tropical areas is "non-specific". A new kind of tuberculin, obtained as supernatant after acid precipitation followed by alcohol precipitation of the unheated concentrate from ultrafiltration of a culture of tubercle bacilli of human type, has been compared with ordinary tuberculin by skin tests in man in East Africa (Malawi) and South India. The results, reported in this paper, indicate that the new preparation gives rise to much smaller non-specific reactions than does the ordinary tuberculin.
目前用于人体皮肤试验的这类结核菌素制剂并非结核感染所特有。尤其有理由相信，在许多热带地区高度流行的那种低度结核菌素敏感性是“非特异性的”。一种新型结核菌素，是通过对人型结核杆菌培养物超滤后的未加热浓缩物进行酸沉淀，然后酒精沉淀，取上清液得到的，已在东非（马拉维）和南印度对人体进行皮肤试验，与普通结核菌素作了比较。本文报道的结果表明，这种新制剂引起的非特异性反应比普通结核菌素小得多。
