小鼠基因控制的免疫无反应性的细胞基础：T细胞中的耐受性诱导。
A cellular basis for genetically controlled immunologic unresponsiveness in mice: tolerance induction in T-cells.
作者信息
Gershon R K, Maurer P H, Merryman C F
出版信息
Proc Natl Acad Sci U S A. 1973 Jan;70(1):250-4. doi: 10.1073/pnas.70.1.250.
Abstract
H-2(q) mice (DBA/1) do not make an antibody response to a synthetic aminoacid polymer, (Glu, Ala,Tyr(10)), after an immunizing regimen that produces a good antibody response in mouse strains with other H-2 alleles. Their thymocytes, however, show evidence of recognizing this antigen since they synthesize DNA when they meet the antigen in the spleen. This recognition event does not lead to memory production, as it does in genetic responders, since the thymocytes fail to respond to a second immunization with (Glu,Ala,Tyr(10)). Nonresponder mice do make antibody to (Glu,Ala,Tyr(10)) when they are immunized with it complexed to an immunogenic carrier, but previous treatment with free polymer can temporarily abolish this response. Thus, we suggest that the basis for the unresponsiveness of these mice is that their T-cells (thymus-processed lymphocytes) have an inordinate propensity to become (or to induce other cells to become) immunologically tolerant.
摘要
H-2(q)小鼠（DBA/1）在经过一种免疫方案后，对合成氨基酸聚合物（Glu，Ala，Tyr(10)）不会产生抗体反应，而该免疫方案在具有其他H-2等位基因的小鼠品系中能产生良好的抗体反应。然而，它们的胸腺细胞显示出识别这种抗原的迹象，因为当它们在脾脏中遇到抗原时会合成DNA。这种识别事件不会像在基因反应者中那样导致记忆产生，因为胸腺细胞对用（Glu，Ala，Tyr(10)）进行的第二次免疫没有反应。无反应小鼠在用与免疫原性载体结合的（Glu，Ala，Tyr(10)）进行免疫时会产生针对它的抗体，但先前用游离聚合物处理可暂时消除这种反应。因此，我们认为这些小鼠无反应性的基础是它们的T细胞（经胸腺处理的淋巴细胞）有过度倾向于变得（或诱导其他细胞变得）免疫耐受。
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