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血管紧张素II对大鼠纹状体切片中新合成的[3H]多巴胺自发释放的刺激作用。

Stimulating effect of angiotensin II on the spontaneous release of newly synthetized [3H]dopamine in rat striatal slices.

作者信息

Simonnet G, Giorguieff-Chesselet M F

出版信息

Neurosci Lett. 1979 Dec;15(2-3):153-8. doi: 10.1016/0304-3940(79)96105-6.

DOI:10.1016/0304-3940(79)96105-6
PMID:530525
Abstract

Angiotensin II (A II) (10(-6) M, 10(-5) M, 5 . 10(-5) M) stimulated the spontaneous release of [3H]dopamine (DA) continuously synthetized from [3H]tyrosine in striatal slices of the rat. The A II-evoked release of [3H]-DA was prevented when slices were superfused with a calcium-free medium containing EGTA 5 . 10(-4) M. It was also suppressed in the presence of the potent antagonist Sar1-Ile8-angiotensin.

摘要

血管紧张素II（A II）（10⁻⁶ M、10⁻⁵ M、5×10⁻⁵ M）刺激大鼠纹状体切片中由[³H]酪氨酸持续合成的[³H]多巴胺（DA）的自发释放。当切片在含有5×10⁻⁴ M乙二醇双乙醚二胺四乙酸（EGTA）的无钙培养基中灌流时，A II诱发的[³H] - DA释放被阻止。在强效拮抗剂Sar1 - Ile8 - 血管紧张素存在的情况下，它也受到抑制。

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