Staubesand J, Fischer N
Pathol Res Pract. 1979 Dec;165(4):374-91. doi: 10.1016/s0344-0338(79)80031-x.
Quite diverse pathological changes of the wall of a blood-vessel can lead to quantitatively and qualitatively altered collagen, as well as to the production of matrix vesicles. It can be demonstrated morphologically that changes--particularly qualitative changes--in collagen are accompanied by a more or less severe loss of function. Possible causal connections between the appearance simultaneously of matrix vesicles (in which lysosomal enzymes can be demonstrated) and altered vascular collagen are discussed.
血管壁多种多样的病理变化可导致胶原蛋白在数量和质量上发生改变，以及基质小泡的产生。形态学上可以证明，胶原蛋白的变化，尤其是质量上的变化，会或多或少地伴随着功能的严重丧失。本文讨论了基质小泡（其中可证明存在溶酶体酶）与血管胶原蛋白改变同时出现之间可能的因果关系。
