Oshiumi Y, Yagi H, Nishitani H, Yamawaki H, Nakayama C, Kamoi I, Matsuura K, Momose S
Radioisotopes. 1979 Jun;28(6):367-70. doi: 10.3769/radioisotopes.28.6_367.
Non-infected urine samples of twenty six preoperative bladder cancers were examined by urinary CEA radioimmunoassay and exfoliative cytology. There were 65% of urinary CEA positivity and 58% of cytological positivity (class III, IV, V). CEA measurements were positive in 8 of 11 negative cytology cases (class I and II). Exfoliative cytological examination failed to detect most of well differentiated transitional cell carcinomas, while urinary CEA study detected 4 of 6 such cases. Combination of both urinary CEA measurement and cytology resulted in 85% of positivity. Therefore we recommend routine use of this combination as a screening system of bladder cancer.
采用尿癌胚抗原放射免疫测定法和脱落细胞学检查法，对26例术前膀胱癌患者的未感染尿样进行检测。尿癌胚抗原阳性率为65%，细胞学阳性率（Ⅲ、Ⅳ、Ⅴ级）为58%。在11例细胞学检查阴性（Ⅰ级和Ⅱ级）的病例中，有8例癌胚抗原检测呈阳性。脱落细胞学检查未能检测出大多数高分化移行细胞癌，而尿癌胚抗原研究检测出6例此类病例中的4例。尿癌胚抗原测定和细胞学检查相结合，阳性率达85%。因此，我们建议常规使用这种联合检测作为膀胱癌的筛查系统。
