Vik-Mo H, Riemersma R A, Mjøs O D, Oliver M F
Scand J Clin Lab Invest. 1979 Oct;39(6):559-68. doi: 10.1080/00365517909108834.
Myocardial metabolism was studied in open-chest dogs before and during induction of myocardial ischaemia by coronary artery occlusion. Blood was sampled from a local coronary vein draining ischaemic tissue and from coronary sinus draining predominantly nonischaemic tissue. In the basal state, induction of myocardial ischaemia stimulated myocardial lipolysis as shown by release of glycerol from the ischaemic zone. During isoprenaline infusion, free fatty acids (FFA) extraction across the ischaemic myocardium was substantially increased, but no glycerol release occurred. Pretreatment with nicotinic acid or sodium salicylate markedly depressed FFA extraction across ischaemic myocardium, both during basal and isoprenaline stimulated lipolysis and nicotinic acid most likely inhibited lipolysis in the ischaemic zone. Thus, reduced severity of acute ischaemic injury by antilipolytic treatment might be due to a combination of inhibited myocardial lipolysis and reduced FFA extraction.
在开胸犬身上，研究了冠状动脉闭塞诱导心肌缺血之前及期间的心肌代谢情况。从引流缺血组织的局部冠状静脉以及主要引流非缺血组织的冠状窦采集血液样本。在基础状态下，心肌缺血的诱导刺激了心肌脂解，这表现为缺血区甘油的释放。在输注异丙肾上腺素期间，缺血心肌对游离脂肪酸（FFA）的摄取显著增加，但未发生甘油释放。用烟酸或水杨酸钠预处理可显著降低缺血心肌对FFA的摄取，无论是在基础状态还是异丙肾上腺素刺激的脂解过程中，烟酸很可能抑制了缺血区的脂解。因此，抗脂解治疗减轻急性缺血性损伤的严重程度可能是由于抑制心肌脂解和减少FFA摄取共同作用的结果。
