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通过在小鼠体内施用抗独特型抗体诱导对人肿瘤标志物的免疫。

Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.

作者信息

Nepom G T, Nelson K A, Holbeck S L, Hellström I, Hellström K E

出版信息

Proc Natl Acad Sci U S A. 1984 May;81(9):2864-7. doi: 10.1073/pnas.81.9.2864.

DOI:10.1073/pnas.81.9.2864
PMID:6609369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC345172/
Abstract

Anti-idiotypic antibodies are described that were raised against murine monoclonal antibody 8.2, an antibody specific for a human melanoma-associated cell surface marker called p97. The 8.2 idiotopes recognized by this anti-idiotypic antiserum are binding site-associated and are shared by other monoclonal anti-p97 antibodies with the same specificity as antibody 8.2. Mice immunized with the anti-idiotype demonstrate delayed-type hypersensitivity reactions when challenged with melanoma (p97-positive) tumor cells.

摘要

已描述了针对鼠单克隆抗体8.2产生的抗独特型抗体，该抗体对一种名为p97的人黑素瘤相关细胞表面标志物具有特异性。这种抗独特型抗血清识别的8.2独特型表位与结合位点相关，并且与其他具有与抗体8.2相同特异性的抗p97单克隆抗体共享。用抗独特型免疫的小鼠在用黑素瘤（p97阳性）肿瘤细胞攻击时表现出迟发型超敏反应。

相似文献

1
Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.通过在小鼠体内施用抗独特型抗体诱导对人肿瘤标志物的免疫。
Proc Natl Acad Sci U S A. 1984 May;81(9):2864-7. doi: 10.1073/pnas.81.9.2864.
2
Analysis of the idiotypic network in tumor immunity.肿瘤免疫中独特型网络的分析。
J Immunol. 1987 Dec 1;139(11):3902-10.
3
Tumor-specific idiotype vaccines. I. Generation and characterization of internal image tumor antigen.肿瘤特异性独特型疫苗。I. 内影像肿瘤抗原的产生与特性
J Immunol. 1986 Sep 1;137(5):1743-9.
4
Monoclonal antiidiotypic antibodies related to a murine oncofetal bladder tumor antigen induce specific cell-mediated tumor immunity.与鼠癌胚膀胱肿瘤抗原相关的单克隆抗独特型抗体可诱导特异性细胞介导的肿瘤免疫。
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6286-90. doi: 10.1073/pnas.82.18.6286.
5
Immunotherapy of murine sarcomas with auto-anti-idiotypic monoclonal antibodies which bind to tumor-specific T cells.用与肿瘤特异性T细胞结合的自身抗独特型单克隆抗体对小鼠肉瘤进行免疫治疗。
J Immunol. 1987 Sep 15;139(6):2110-7.
6
Towards an idiotype vaccine against mammary tumors. Induction of an immune response to breast cancer-associated antigens by anti-idiotypic antibodies.迈向针对乳腺肿瘤的独特型疫苗。抗独特型抗体诱导对乳腺癌相关抗原的免疫反应。
Eur J Immunol. 1988 Nov;18(11):1713-8. doi: 10.1002/eji.1830181109.
7
Idiotypic cascade in the human high molecular weight melanoma-associated antigen system: fine specificity and idiotypic profile of anti-anti-idiotypic monoclonal antibodies.人类高分子量黑色素瘤相关抗原系统中的独特型级联：抗抗独特型单克隆抗体的精细特异性和独特型谱
Eur J Immunol. 1993 Jul;23(7):1671-7. doi: 10.1002/eji.1830230741.
8
Induction of antibody and cellular immune responses in chickens against Eimeria tenella by anti-idiotype.
Prog Clin Biol Res. 1987;238:307-20.
9
Tumor-specific idiotype vaccines. II. Analysis of the tumor-related network response induced by the tumor and by internal image antigens (Ab2 beta).肿瘤特异性独特型疫苗。II. 肿瘤及内影像抗原（Ab2β）诱导的肿瘤相关网络反应分析。
J Immunol. 1987 Jul 1;139(1):271-8.
10
Antibody response against a possible arthritogenic epitope on human type II collagen induced by anti-idiotypic antibody.抗独特型抗体诱导的针对人II型胶原上可能的致关节炎表位的抗体应答。
J Immunol. 1989 Mar 1;142(5):1487-94.

引用本文的文献

1
Diagnostic and therapeutic use of monoclonal antibodies to human tumor antigens.针对人类肿瘤抗原的单克隆抗体的诊断和治疗用途。
Med Oncol Tumor Pharmacother. 1984;1(3):143-7. doi: 10.1007/BF02934135.
2
Monoclonal antiidiotypic antibodies related to a murine oncofetal bladder tumor antigen induce specific cell-mediated tumor immunity.与鼠癌胚膀胱肿瘤抗原相关的单克隆抗独特型抗体可诱导特异性细胞介导的肿瘤免疫。
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6286-90. doi: 10.1073/pnas.82.18.6286.
3
Vaccination with syngeneic monoclonal anti-idiotype protects against a tumour challenge.用同基因单克隆抗独特型抗体进行疫苗接种可抵御肿瘤攻击。
Immunology. 1987 Feb;60(2):181-6.
4
Recombinant vaccinia virus vaccine against the human melanoma antigen p97 for use in immunotherapy.用于免疫治疗的抗人黑素瘤抗原p97重组痘苗病毒疫苗。
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1052-6. doi: 10.1073/pnas.85.4.1052.
5
Idiotypic vaccines and infectious diseases.独特型疫苗与传染病
Infect Immun. 1988 Jun;56(6):1407-13. doi: 10.1128/iai.56.6.1407-1413.1988.
6
Possible role of anti-idiotypic antibodies in the induction of tumor immunity.抗独特型抗体在肿瘤免疫诱导中的可能作用。
J Clin Invest. 1987 Nov;80(5):1217-24. doi: 10.1172/JCI113195.
7
Anti-idiotypic antibodies and the induction of specific tumor immunity.抗独特型抗体与特异性肿瘤免疫的诱导
Cancer Metastasis Rev. 1987;6(4):489-502. doi: 10.1007/BF00047464.
8
Cross-reactive variable-region associated epitopes of human IgG1 lambda paraprotein detected by a monoclonal antibody panel.通过单克隆抗体组检测到的人IgG1λ副蛋白的交叉反应性可变区相关表位
Immunology. 1987 Jul;61(3):247-54.
9
Suppression of in vivo tumor formation induced by simian virus 40-transformed cells in mice receiving antiidiotypic antibodies.在接受抗独特型抗体的小鼠中，猿猴病毒40转化细胞诱导的体内肿瘤形成受到抑制。
J Exp Med. 1985 Jun 1;161(6):1432-49. doi: 10.1084/jem.161.6.1432.
10
Vaccination against tumor cells expressing breast cancer epithelial tumor antigen.针对表达乳腺癌上皮肿瘤抗原的肿瘤细胞进行疫苗接种。
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9498-502. doi: 10.1073/pnas.87.23.9498.

本文引用的文献

1
Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma-associated antigen p97.人黑色素瘤细胞在体外可被一种针对黑色素瘤相关抗原p97的免疫毒素杀死。
Int J Cancer. 1982 Oct 15;30(4):437-43. doi: 10.1002/ijc.2910300410.
2
Human melanoma-associated antigen p97 is structurally and functionally related to transferrin.人类黑色素瘤相关抗原p97在结构和功能上与转铁蛋白相关。
Nature. 1982 Mar 11;296(5853):171-3. doi: 10.1038/296171a0.
3
Anti-idiotypes to monoclonal anti-H-2 antibodies. II. Expression of anti-H-2Kk idiotypes on antibodies induced by anti-idiotype or H-2Kk antigen.抗单克隆抗-H-2抗体的独特型。II. 抗独特型或H-2Kk抗原诱导产生的抗体上抗-H-2Kk独特型的表达
J Exp Med. 1981 Nov 1;154(5):1305-18. doi: 10.1084/jem.154.5.1305.
4
The genetic and cellular basis of regulation of the immune response to tumor antigens.对肿瘤抗原免疫应答调控的遗传和细胞基础。
Contemp Top Immunobiol. 1980;11:81-116. doi: 10.1007/978-1-4684-3701-0_2.
5
Idiotypes of anti-Ia antibodies. II. Effects of in vivo treatment with xenogeneic anti-idiotype.抗Ia抗体的独特型。II. 异种抗独特型体内治疗的效果。
J Immunol. 1982 Oct;129(4):1545-52.
6
Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies.使用抗独特型抗体对小鼠进行非洲锥虫病免疫接种。
J Exp Med. 1982 Apr 1;155(4):1108-19. doi: 10.1084/jem.155.4.1108.
7
Suppression of tumor rejection by autologous anti-idiotypic immunity.自体抗独特型免疫对肿瘤排斥反应的抑制作用。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2209-13. doi: 10.1073/pnas.77.4.2209.
8
Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.人类恶性黑色素瘤的细胞表面抗原：用小鼠单克隆抗体对六种抗原系统的定义
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6114-8. doi: 10.1073/pnas.77.10.6114.
9
Enhanced Detection of immunoglobulin binding by a modified ELISA.通过改良酶联免疫吸附测定法增强免疫球蛋白结合的检测
J Immunol Methods. 1983 May 27;60(1-2):47-52. doi: 10.1016/0022-1759(83)90333-2.
10
Induction or elimination of tumor-specific immunity against a chemically-induced rat tumor using auto-anti-idiotypic immunity.利用自身抗独特型免疫诱导或消除针对化学诱导大鼠肿瘤的肿瘤特异性免疫。
Int J Cancer. 1982 Apr 15;29(4):417-23. doi: 10.1002/ijc.2910290410.