Nepom G T, Nelson K A, Holbeck S L, Hellström I, Hellström K E
Proc Natl Acad Sci U S A. 1984 May;81(9):2864-7. doi: 10.1073/pnas.81.9.2864.
Anti-idiotypic antibodies are described that were raised against murine monoclonal antibody 8.2, an antibody specific for a human melanoma-associated cell surface marker called p97. The 8.2 idiotopes recognized by this anti-idiotypic antiserum are binding site-associated and are shared by other monoclonal anti-p97 antibodies with the same specificity as antibody 8.2. Mice immunized with the anti-idiotype demonstrate delayed-type hypersensitivity reactions when challenged with melanoma (p97-positive) tumor cells.
已描述了针对鼠单克隆抗体8.2产生的抗独特型抗体,该抗体对一种名为p97的人黑素瘤相关细胞表面标志物具有特异性。这种抗独特型抗血清识别的8.2独特型表位与结合位点相关,并且与其他具有与抗体8.2相同特异性的抗p97单克隆抗体共享。用抗独特型免疫的小鼠在用黑素瘤(p97阳性)肿瘤细胞攻击时表现出迟发型超敏反应。