抗菌药物与抗肿瘤抗生素联合应用对革兰氏阴性杆菌的杀菌作用。
Bactericidal effect of combinations of antimicrobial drugs and antineoplastic antibiotics against gram-negative bacilli.
作者信息
Michel J, Jacobs J Y, Sacks T
出版信息
Antimicrob Agents Chemother. 1979 Dec;16(6):761-6. doi: 10.1128/AAC.16.6.761.
Abstract
Six antineoplastic antibiotics showed little antibacterial activity against 28 strains of four species of gram-negative enteric bacteria. By using the cellophane transfer technique, combinations of these agents with 16 antibacterial drugs usually showed indifference. However, combinations of mitomycin C, especially with the aminoglycosides, were synergistic on strains of Escherichia coli, Proteus, and Klebsiella pneumoniae. Bleomycin, on the other hand, often showed antagonism on strains of E. coli and K. pneumoniae with the beta-lactams, aminoglycosides, and other antibacterial agents. Checkerboard titrations and kinetic killing curves confirmed these findings.
摘要
六种抗肿瘤抗生素对28株四种革兰氏阴性肠道细菌几乎没有抗菌活性。通过使用玻璃纸转移技术，这些药物与16种抗菌药物的组合通常表现为无相互作用。然而，丝裂霉素C的组合，特别是与氨基糖苷类药物的组合，对大肠杆菌、变形杆菌和肺炎克雷伯菌菌株具有协同作用。另一方面，博来霉素与β-内酰胺类、氨基糖苷类和其他抗菌药物联合使用时，对大肠杆菌和肺炎克雷伯菌菌株常表现出拮抗作用。棋盘滴定法和动态杀菌曲线证实了这些发现。
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