β-内酰胺类抗生素与抗肿瘤药物的相互作用。
Interactions of beta-lactam antibiotics and antineoplastic agents.
作者信息
Ueda Y, Saito A, Fukuoka Y, Yamashiro Y, Ikeda Y, Taki H, Yasuda T, Saikawa I
出版信息
Antimicrob Agents Chemother. 1983 Mar;23(3):374-8. doi: 10.1128/AAC.23.3.374.
Abstract
The in vitro interactions of four beta-lactam antibiotics and five antineoplastic agents were examined with 100 clinically isolated strains of four species of gram-negative bacilli. Generally, by the checkerboard dilution method, beta-lactam antibiotics, when tested in combination with mitomycin C, bleomycin, or 5-fluorouracil, showed synergistic action, whereas when tested in combination with carboquone, they showed antagonistic action. Almost no combinations of adriamycin showed the interactions. Among beta-lactam antibiotics, piperacillin was more frequently synergistic than cefoperazone, cefazolin, or carbenicillin when tested in combination with each antineoplastic agent against various species.
摘要
用100株从临床上分离出的4种革兰氏阴性杆菌，检测了4种β-内酰胺类抗生素与5种抗肿瘤药物的体外相互作用。一般来说，通过棋盘稀释法，β-内酰胺类抗生素与丝裂霉素C、博来霉素或5-氟尿嘧啶联合测试时显示协同作用，而与卡波醌联合测试时则显示拮抗作用。阿霉素的几乎所有组合均未显示出相互作用。在β-内酰胺类抗生素中，哌拉西林与每种抗肿瘤药物联合测试针对不同菌种时，比头孢哌酮、头孢唑林或羧苄西林更常显示协同作用。
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