抗菌药物与抗肿瘤抗生素联合使用对金黄色葡萄球菌的杀菌作用。
Bactericidal effect of combinations of antimicrobial drugs and antineoplastic antibiotics against Staphylococcus aureus.
作者信息
Jacobs J Y, Michel J, Sacks T
出版信息
Antimicrob Agents Chemother. 1979 Apr;15(4):580-6. doi: 10.1128/AAC.15.4.580.
Abstract
Six antineoplastic antibiotics were tested against ten strains of Staphylococcus aureus. Four showed bacteriostatic and/or bactericidal activity against each of the ten strains, and two were only bacteriostatic for seven and nine strains, respectively. Using the cellophane transfer technique, combinations of these antineoplastic antibiotics with 16 antibacterial drugs were screened for combined bactericidal activity. Synergism or antagonism was demonstrated in about one-third of the combinations. Checkerboard titrations and killing curves confirmed these findings and indicated that the effective concentrations of the antibacterial agents were similar to those attainable in the serum after therapeutic doses of these drugs. Although the pharmacokinetics of the six antineoplastic antibiotics in humans are not fully known, at least one of them has a peak serum level corresponding to those values at which a bactericidal effect was produced in vitro.
摘要
对六种抗肿瘤抗生素进行了针对十株金黄色葡萄球菌的测试。其中四种对这十株菌株中的每一株都显示出抑菌和/或杀菌活性，另外两种分别仅对七株和九株菌株具有抑菌作用。使用玻璃纸转移技术，对这些抗肿瘤抗生素与16种抗菌药物的组合进行了联合杀菌活性筛选。约三分之一的组合表现出协同或拮抗作用。棋盘滴定法和杀菌曲线证实了这些发现，并表明抗菌剂的有效浓度与这些药物治疗剂量后血清中可达到的浓度相似。尽管这六种抗肿瘤抗生素在人体内的药代动力学尚未完全明确，但其中至少有一种的血清峰值水平与体外产生杀菌作用时的值相对应。
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