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洗必泰在体外和体内均是对抗沙眼衣原体的有效药物。

Chlorhexidine as an effective agent against Chlamydia trachomatis in vitro and in vivo.

作者信息

Nisbet I T, Graham D M, Spicer P E, Tibbs G J

出版信息

Antimicrob Agents Chemother. 1979 Dec;16(6):855-7. doi: 10.1128/AAC.16.6.855.

DOI:10.1128/AAC.16.6.855
PMID:533265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352965/
Abstract

In a small field trial, chlorhexidine (50 micrograms/ml) was as effective against clinical trachoma as topical tetracyclines or oral co-trimoxazole; in vitro, 2.5 micrograms/ml was chlamydicidal.

摘要

在一项小型现场试验中，洗必泰（50微克/毫升）对临床沙眼的疗效与局部用四环素或口服复方新诺明相当；在体外，2.5微克/毫升具有杀衣原体作用。

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本文引用的文献

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Observatios on the growth of trachoma and inclusion blennorrhoea viruses in embryonate eggs.沙眼病毒和包涵体性脓漏眼病毒在鸡胚中的生长观察
J Hyg (Lond). 1963 Mar;61(1):67-75. doi: 10.1017/s0022172400020751.
2
1:6-Di-4'-chlorophenyldiguanidohexane (hibitane); laboratory investigation of a new antibacterial agent of high potency.1,6 - 二 - 4'-氯苯基双胍己烷（洗必泰）；一种高效新型抗菌剂的实验室研究
Br J Pharmacol Chemother. 1954 Jun;9(2):192-6. doi: 10.1111/j.1476-5381.1954.tb00840.x.
3
The cytology of conjunctival smears from aboriginal school children at Yalata, South Australia.南澳大利亚亚拉塔地区原住民学童结膜涂片的细胞学研究。
Am J Ophthalmol. 1967 May;63(5):Suppl:1538-40.
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Controlled trials with trisulfapyrimidines in the treatment of chronic trachoma.
J Infect Dis. 1969 Jun;119(6):581-90. doi: 10.1093/infdis/119.6.581.
5
Lymphogranuloma venereum in Australia. 1. Clinical aspects of the disease and isolation and identification of the causal agent from a patient in Melbourne.澳大利亚的性病性淋巴肉芽肿。1. 该疾病的临床特征以及从墨尔本一名患者身上分离和鉴定病原体。
Med J Aust. 1974 Aug 17;2(7):239-43. doi: 10.5694/j.1326-5377.1974.tb70740.x.
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Doxycycline treatment of chronic trachoma.
JAMA. 1973 Apr 9;224(2):220-3.
7
Studies on the epidemiology, microbiology and immunology of trachoma among children at three centres in Western Australia.西澳大利亚三个中心儿童沙眼的流行病学、微生物学及免疫学研究。
Med J Aust. 1973 Aug 25;2(8):353-60. doi: 10.5694/j.1326-5377.1973.tb115111.x.
8
The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man.漱口水和洗必泰局部应用对人体牙菌斑形成及牙龈炎的影响。
J Periodontal Res. 1970;5(2):79-83. doi: 10.1111/j.1600-0765.1970.tb00696.x.
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Controlled treatment trials of trachoma in American Indian children.
Lancet. 1967 Nov 4;2(7523):961-4. doi: 10.1016/s0140-6736(67)90796-9.
10
Severe endemic trachoma in tunisia. II. A controlled therapy trial of topically applied chlortetracycline and erythromycin.突尼斯的严重地方性沙眼。II. 局部应用金霉素和红霉素的对照治疗试验。
Arch Ophthalmol. 1974 Sep;92(3):198-203. doi: 10.1001/archopht.1974.01010010206003.