Jeffrey G M, Gibson F D
Bull World Health Organ. 1966;35(3):441-9.
The emergence of strains of Plasmodium falciparum resistant to normal dosages of chloroquine or other 4-aminoquinolines has caused concern in a number of malarious areas. Well-documented reports have confirmed this resistance in wide areas of South-East Asia and in some areas of South America. Occasional reports have been received from parts of West Africa, and the present investigation sought to clarify the situation in two areas, Ouagadougou, Upper Volta, and Kpain, Liberia, from which such reports had emanated. Studies were carried out to determine the sensitivity of local strains of P. falciparum to chloroquine. The results, based on the rapidity of parasite clearance, indicated a normal sensitivity in the cases treated. Although it is concluded that strains of P. falciparum with significant resistance to chloroquine are not at present a problem in the areas concerned, a watch should be kept for the possible future emergence of this problem.
恶性疟原虫对常规剂量氯喹或其他4-氨基喹啉产生耐药性，已在一些疟疾流行地区引起关注。有充分文献记载的报告已证实，东南亚广大地区和南美洲部分地区存在这种耐药性。西非部分地区也偶尔有报告，本次调查旨在澄清来自上沃尔特的瓦加杜古和利比里亚的卡潘这两个地区的情况，此前已有关于这两个地区的此类报告。开展了研究以确定当地恶性疟原虫菌株对氯喹的敏感性。基于寄生虫清除速度的结果表明，所治疗病例具有正常敏感性。虽然得出结论认为，目前在有关地区，对氯喹具有显著耐药性的恶性疟原虫菌株不是一个问题，但应密切关注该问题未来可能出现的情况。
