茶碱和抗利尿激素引起的蛙皮电容变化
Capacitance changes in frog skin caused by theophylline and antidiuretic hormone.
作者信息
Cuthbert A W, Painter E
出版信息
Br J Pharmacol. 1969 Sep;37(1):314-24. doi: 10.1111/j.1476-5381.1969.tb09549.x.
Abstract
- Impedance loci for frog skins have been calculated by computer analysis from voltage transients developed across the tissues.2. Attention has been paid to simultaneous changes in conductance and capacitance of skins treated either with antidiuretic hormone (ADH) or with theophylline. These drugs always caused an increase in conductance and usually the skin capacitance also increased. However, changes in conductance were not correlated with capacitance changes.3. Changes in capacitance caused by the drugs may represent pore formation in the barrier to water flow, since both drugs increase hydro-osmotic flow in epithelia. If this interpretation is correct, then 0.14% of the membrane area forms water-permeable pores in response to a maximal dose of ADH. This value is somewhat less than the value obtained previously (0.3%) by graphical analysis.4. A theoretical account is given of the relative accuracy of the computer method and the graphical method for voltage transient analysis.
摘要
蛙皮的阻抗轨迹已通过计算机分析，根据组织上产生的电压瞬变来计算。
已关注用抗利尿激素（ADH）或茶碱处理的皮肤的电导和电容的同时变化。这些药物总是导致电导增加，并且通常皮肤电容也增加。然而，电导的变化与电容的变化不相关。
药物引起的电容变化可能代表水流动屏障中形成了孔，因为两种药物都增加上皮中的水渗透流。如果这种解释正确，那么响应最大剂量的ADH，0.14%的膜面积形成了透水孔。该值略小于先前通过图形分析获得的值（0.3%）。
对电压瞬变分析的计算机方法和图形方法的相对准确性给出了理论说明。
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