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大鼠体内抗原敏感细胞的密度分布分析

Density distribution analysis of antigen-sensitive cells in the rat.

作者信息

Haskill J S

出版信息

J Exp Med. 1969 Oct 1;130(4):877-93. doi: 10.1084/jem.130.4.877.

DOI:10.1084/jem.130.4.877
PMID:5343439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138721/
Abstract

Analysis of the cell populations capable of initiating a response to sheep and horse erythrocyte antigens has been carried out by means of equilibrium density gradient centrifugation. The results indicate that there are at least six distinguishable AS cell populations for sheep erythrocytes, but only three for horse erythrocytes in the spleen of the Lewis rat. Evidence is presented for the existence of metabolic, physiological, and immunological differences among these populations. It is suggested that at least one population of AS cells responds only to the specific antigen and at least one other population is sensitive to stimulation by a broad range of antigens. It is assumed that the difference between these two AS cells results from a process of differentiation of AS cells primed into DNA synthesis by antigen stimulation.

摘要

通过平衡密度梯度离心法对能够启动对绵羊和马红细胞抗原反应的细胞群体进行了分析。结果表明，在Lewis大鼠的脾脏中，针对绵羊红细胞至少有六个可区分的AS细胞群体，而针对马红细胞只有三个。文中提供了这些群体之间存在代谢、生理和免疫学差异的证据。有人提出，至少有一个AS细胞群体仅对特定抗原作出反应，至少还有一个群体对多种抗原的刺激敏感。据推测，这两种AS细胞之间的差异是由抗原刺激引发进入DNA合成的AS细胞分化过程导致的。

相似文献

1
Density distribution analysis of antigen-sensitive cells in the rat.大鼠体内抗原敏感细胞的密度分布分析
J Exp Med. 1969 Oct 1;130(4):877-93. doi: 10.1084/jem.130.4.877.
2
Density distribution analysis of antigen sensitive cells in the rat.大鼠体内抗原敏感细胞的密度分布分析
Nature. 1967 Dec 23;216(5121):1229-31. doi: 10.1038/2161229a0.
3
In vitro studies of chicken lymphoid cells. II. The anamnestic response of spleen cells from control-irradiated and bursectomized-irradiated chickens to sheep erythrocytes.鸡淋巴细胞的体外研究。II. 对照照射和法氏囊切除照射鸡的脾细胞对绵羊红细胞的回忆反应。
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4
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5
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Immunological restoration of the locally irradiated spleen with circulating lymphocytes.
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9
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10
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Immunology. 1973 Feb;24(2):343-63.

引用本文的文献

1
Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells.能够使大多数分离出的三硝基苯酚结合B细胞发生抗原特异性激活的条件的定义。
J Exp Med. 1982 Dec 1;156(6):1635-49. doi: 10.1084/jem.156.6.1635.
2
The role of nonlymphoid accessory cells in the immune response to different antigens.非淋巴细胞辅助细胞在针对不同抗原的免疫反应中的作用。
J Exp Med. 1970 Mar 1;131(3):461-82. doi: 10.1084/jem.131.3.461.
3
In vitro and in vivo studies of the immune response to sheep erythrocytes using partially purified cell preparations.使用部分纯化的细胞制剂对绵羊红细胞免疫反应的体外和体内研究。
J Exp Med. 1970 Jan 1;131(1):57-76. doi: 10.1084/jem.131.1.57.
4
Density distribution analysis of a primary antibody forming cell response.一抗形成细胞反应的密度分布分析
Immunology. 1971 Jun;20(6):919-30.
5
Immunological activity of blood lymphocyte fractions. A study by the macrophage electrophoretic mobility method.血液淋巴细胞组分的免疫活性。巨噬细胞电泳迁移率法研究。
Clin Exp Immunol. 1972 Apr;10(4):571-9.
6
Localization of functionally different guinea-pig spleen cells in albumin gradients.功能不同的豚鼠脾细胞在白蛋白梯度中的定位
Immunology. 1972 Mar;22(3):417-21.
7
Degeneracy of the immune response to sheep red cells.对绵羊红细胞免疫反应的简并性。
Immunology. 1972 Sep;23(3):321-34.
8
Separation of stages in the development of the "T" cells involved in cell-mediated immunity.参与细胞介导免疫的 “T” 细胞发育阶段的分离。
J Exp Med. 1972 Jun 1;135(6):1375-91. doi: 10.1084/jem.135.6.1375.
9
Increased production of plaque-forming cells in mouse lymph nodes following regional injection of a second antigen.在局部注射第二种抗原后，小鼠淋巴结中形成斑块细胞的产量增加。
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10
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J Exp Med. 1976 May 1;143(5):1220-38. doi: 10.1084/jem.143.5.1220.

本文引用的文献

1
Cellular events in the immune response : analysis and in vitro response of mouse spleen cell populations separated by differential flotation in albumin gradients.免疫反应中的细胞事件：用白蛋白梯度微分漂浮法分离的小鼠脾细胞群体的分析和体外反应。
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2
THE ANTIBODY RESPONSE OF RATS DEPLETED OF LYMPHOCYTES BY CHRONIC DRAINAGE FROM THE THORACIC DUCT.经胸导管慢性引流耗尽淋巴细胞的大鼠的抗体反应。
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3
THE MECHANISM OF TOLERANCE PRODUCED IN RATS TO SHEEP ERYTHROCYTES. II. THE PLAQUE-FORMING CELL AND ANTIBODY RESPONSE TO MULTIPLE INJECTIONS OF ANTIGEN BEGUN AT BIRTH.大鼠对绵羊红细胞产生耐受性的机制。II. 对出生时开始多次注射抗原的空斑形成细胞及抗体反应
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4
Density distribution analysis of antigen sensitive cells in the rat.大鼠体内抗原敏感细胞的密度分布分析
Nature. 1967 Dec 23;216(5121):1229-31. doi: 10.1038/2161229a0.
5
Density distribution analysis of lymphocyte populations.淋巴细胞群体的密度分布分析。
Nature. 1967 Dec 23;216(5121):1227-8. doi: 10.1038/2161227a0.
6
Antigenic competition: cellular or humoral.抗原竞争：细胞性或体液性。
Science. 1967 Oct 27;158(3800):512-4. doi: 10.1126/science.158.3800.512.
7
The proliferative state of antigen-sensitive precursors of hemolysin-producing cells, determined by the use of the inhibitor, vinblastine.通过使用抑制剂长春碱来确定产生溶血素细胞的抗原敏感前体的增殖状态。
J Immunol. 1966 Mar;96(3):472-7.
8
The proliferative capacity of antigen-sensitive precursors of hemolytic plaque-forming cells.溶血空斑形成细胞的抗原敏感前体细胞的增殖能力。
J Immunol. 1966 Jun;96(6):973-80.
9
The role of cell number and source in adoptive immunity.细胞数量和来源在过继性免疫中的作用。
Immunology. 1965 Jun;8(6):539-48.
10
Focal antibody production by transferred spleen cells in irradiated mice.照射小鼠中转移脾细胞产生的局灶性抗体
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