呼吸抑制剂对酿酒酵母在适应氧气过程中麦角固醇合成的不同影响。
Differential effect of respiratory inhibitors on ergosterol synthesis by Saccharomyces cerevisiae during adaptation to oxygen.
作者信息
Adams B G, Parks L W
出版信息
J Bacteriol. 1969 Oct;100(1):370-6. doi: 10.1128/jb.100.1.370-376.1969.
Abstract
The effect of different respiratory inhibitors on the ergosterol content of microaerobically grown non-proliferating yeast cultures was monitored during adaptation to oxygen. It was found that dinitrophenol, azide, and cyanide, which act on the mechanism of the respiratory chain, cause a marked stimulation of sterol production. Acriflavine and chloramphenicol, which affect the synthesis of the respiratory apparatus, caused a delay in the onset of ergosterol synthesis or a marked decrease in sterol content. The data obtained provide presumptive evidence that a component of sterol formation is synthesized on the 70S ribosomal system of the mitochondrion and induced in the presence of oxygen.
摘要
在适应氧气的过程中，监测了不同呼吸抑制剂对微需氧培养的非增殖酵母培养物中麦角固醇含量的影响。结果发现，作用于呼吸链机制的二硝基苯酚、叠氮化物和氰化物会显著刺激固醇的产生。影响呼吸器官合成的吖啶黄和氯霉素会导致麦角固醇合成开始延迟或固醇含量显著降低。所获得的数据提供了推测性证据，表明固醇形成的一个成分是在线粒体的70S核糖体系统上合成的，并在有氧条件下被诱导。
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