右旋糖酐的分子压缩
The molecular compression of dextran.
作者信息
Ogston A G, Preston B N
出版信息
Biochem J. 1979 Oct 1;183(1):1-9. doi: 10.1042/bj1830001.
The suggestion is made that, in solution, the flexible-chain molecules of dextran can undergo an osmotic compression as concentration is increased. Approaches are developed described the molecular shrinkage (i) as arising from intra- and inter-molecular forces, (ii) based on the molecular characteristics of the dextran, and (iii) as estimated by viscosity measurements. Comparison with the macroscopic shrinkage of cross-linked dextran (Sephadex) beads [Edmond, Farquhar, Dunstone & Ogston (1968) Biochem. J. 108, 755-763] is made. In all systems studied, the experimental estimates of compression, both from gel-shrinkage and viscosity measurements were in reasonable agreement with theoretical predictions. The interpretation of the viscosity concentration-dependence was applied to compact structures (albumin and Percoll). Their behaviour was in marked contrast with that of dextran. It is noted that molecular compression may be important in considering transport processes in and thermodynamic properties of concentrated systems.
有人提出，在溶液中，随着浓度的增加，葡聚糖的柔性链分子会发生渗透压缩。已开发出一些方法来描述分子收缩：（i）源于分子内和分子间力；（ii）基于葡聚糖的分子特性；（iii）通过粘度测量估算。并与交联葡聚糖（葡聚糖凝胶）珠的宏观收缩进行了比较[埃德蒙、法夸尔、邓斯通和奥格斯顿（1968年）《生物化学杂志》108卷，755 - 763页]。在所有研究的系统中，通过凝胶收缩和粘度测量得到的压缩实验估计值与理论预测值合理吻合。粘度浓度依赖性的解释被应用于致密结构（白蛋白和 Percoll）。它们的行为与葡聚糖的行为形成明显对比。值得注意的是，在考虑浓缩系统中的传输过程和热力学性质时，分子压缩可能很重要。
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