α-萘黄酮：一种烃类细胞毒性和微粒体羟化酶的抑制剂。
Alpha-naphthoflavone: an inhibitor of hydrocarbon cytotoxicity and microsomal hydroxylase.
作者信息
Diamond L, Gelboin H V
出版信息
Science. 1969 Nov 21;166(3908):1023-5. doi: 10.1126/science.166.3908.1023.
PMID:5347522
Abstract
Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell cultures and protects the cells against the inhibition of cell multiplication by these carcinogens. Alphla-nalphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells and in liver microsomes from rats previously treated with polycyclic aromatic hydrocarbons, but not in microsomes from control rats.
摘要
α-萘黄酮可抑制仓鼠胚胎细胞培养物中3,4-苯并芘和7,12-二甲基苯并(a)蒽的代谢，并保护细胞免受这些致癌物对细胞增殖的抑制作用。α-萘黄酮还可抑制诱导的仓鼠胚胎细胞匀浆以及先前用多环芳烃处理过的大鼠肝脏微粒体中的芳烃羟化酶活性，但对对照大鼠的微粒体无此作用。
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