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α-萘黄酮：一种烃类细胞毒性和微粒体羟化酶的抑制剂。

Alpha-naphthoflavone: an inhibitor of hydrocarbon cytotoxicity and microsomal hydroxylase.

作者信息

Diamond L, Gelboin H V

出版信息

Science. 1969 Nov 21;166(3908):1023-5. doi: 10.1126/science.166.3908.1023.

DOI:10.1126/science.166.3908.1023
PMID:5347522
Abstract

Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell cultures and protects the cells against the inhibition of cell multiplication by these carcinogens. Alphla-nalphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells and in liver microsomes from rats previously treated with polycyclic aromatic hydrocarbons, but not in microsomes from control rats.

摘要

α-萘黄酮可抑制仓鼠胚胎细胞培养物中3,4-苯并芘和7,12-二甲基苯并(a)蒽的代谢，并保护细胞免受这些致癌物对细胞增殖的抑制作用。α-萘黄酮还可抑制诱导的仓鼠胚胎细胞匀浆以及先前用多环芳烃处理过的大鼠肝脏微粒体中的芳烃羟化酶活性，但对对照大鼠的微粒体无此作用。

相似文献

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Alpha-naphthoflavone: an inhibitor of hydrocarbon cytotoxicity and microsomal hydroxylase.α-萘黄酮：一种烃类细胞毒性和微粒体羟化酶的抑制剂。
Science. 1969 Nov 21;166(3908):1023-5. doi: 10.1126/science.166.3908.1023.
2
The effects of two isomeric benzoflavones on aryl hydrocarbon hydroxylase and the toxicity and carcinogenicity of polycyclic hydrocarbons.两种异构苯并黄酮对芳烃羟化酶以及多环烃的毒性和致癌性的影响。
Cancer Res. 1972 Apr;32(4):731-6.
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Effect of polycyclic hydrocarbons in vitro an aryl hydrocarbon (benzo(a)pyrene) hydroxylase.多环烃对体外芳烃（苯并(a)芘）羟化酶的影响。
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Some characteristics of hamster liver and lung microsomal aryl hydrocarbon (biphenyl and benzo(a)pyrene) hydroxylation reactions.仓鼠肝脏和肺微粒体芳烃（联苯和苯并(a)芘）羟基化反应的一些特性。
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Polycyclic hydrocarbon-produced toxicity, transformation, and chromosomal aberrations as a function of aryl hydrocarbon hydroxylase activity in cell cultures.多环烃在细胞培养物中产生的毒性、转化及染色体畸变与芳烃羟化酶活性的关系。
Int J Cancer. 1972 Mar 15;9(2):435-51. doi: 10.1002/ijc.2910090223.
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Microsomal aryl hydrocarbon hydroxylases: on their role in polycyclic hydrocarbon carcinogenesis and toxicity and the mechanism of enzyme induction.微粒体芳烃羟化酶：关于它们在多环烃致癌作用和毒性中的作用以及酶诱导机制
Biochem Soc Symp. 1972;34:103-33.
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Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in microsomes from rat tissues: differential inhibition and stimulation by benzoflavones and organic solvents.大鼠组织微粒体中的芳烃（苯并(a)芘）羟化酶：苯并黄酮和有机溶剂的差异抑制与刺激作用
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Enzymatic hydroxylation of benzopyrene and its relationship to cytotoxicity.苯并芘的酶促羟基化作用及其与细胞毒性的关系。
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Microsomal hydroxylases: studies on the mechanism of induction and their role in polycyclic-hydrocarbon action.微粒体羟化酶：诱导机制及其在多环烃作用中的作用研究。
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Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding.芳基烃羟化酶与多环烃肿瘤发生：酶抑制剂7,8-苯并黄酮对肿瘤发生及大分子结合的影响
Proc Natl Acad Sci U S A. 1972 Apr;69(4):824-8. doi: 10.1073/pnas.69.4.824.

引用本文的文献

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Selenium modifies carcinogen metabolism by inhibiting enzyme induction.硒通过抑制酶诱导来改变致癌物代谢。
Biol Trace Elem Res. 1986 Aug;10(2):153-7. doi: 10.1007/BF02795568.
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Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium.α-萘黄酮通过诱导细胞外钙内流和内皮中一氧化氮的形成来诱导血管舒张。
Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):377-85. doi: 10.1007/s00210-003-0820-6. Epub 2003 Oct 15.
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Transformation of hamster cells in vitro by polycyclic hydrocarbons without cytotoxicity.
多环烃在无细胞毒性情况下对仓鼠细胞的体外转化
Proc Natl Acad Sci U S A. 1971 Dec;68(12):2958-61. doi: 10.1073/pnas.68.12.2958.
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The effect of intracellular oxygen on the metabolization of benzo(a)pyrene and benzo(k)fluoranthene. A microspectrofluorometric analysis in single living cells.
Histochemistry. 1974;42(1):75-84. doi: 10.1007/BF00498480.
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