Brunnen P L, Karmody A M, Needham C D
Gut. 1969 Oct;10(10):831-7. doi: 10.1136/gut.10.10.831.
The incidence, clinical and investigative features, treatment, and course of severe oesophagitis in 200 patients seen and followed up in the Thoracic Surgical Department for north east Scotland from 1951 to 1967 are reviewed. The male/female ratio was 1/1.9. The incidence of severe oesophagitis (grades III and IV) approximated to 4.5 per 100,000; there was a dramatic increase from the age of 50 years onwards.Reflux, with or without hiatal hernia, precedes oesophagitis and has an incidence in excess of 86 per 100,000. It is difficult to assess the extent to which reflux produces mild oesophagitis, but it is clear that it only infrequently leads to the severe grades. Severe oesophagitis does not always need operative treatment. A conservative regime, supplemented by bouginage as required, enables the poorer-risk older patient to live a near-normal life span, in very reasonable comfort. Fifty-three patients of the whole series were operated upon, half primarily and half after previous conservative treatment. The problems of operative treatment are discussed. Newer procedures designed to prevent reflux now allow operation to be more freely advised.Perhaps, rather surprisingly, severe oesophagitis had very little effect on the expectation of life, whether treatment was conservative or operative.
本文回顾了1951年至1967年期间在苏格兰东北部胸外科就诊并接受随访的200例严重食管炎患者的发病率、临床及检查特征、治疗方法和病程。男女比例为1/1.9。严重食管炎(III级和IV级)的发病率约为每10万人4.5例;50岁以后发病率急剧上升。食管炎之前常伴有或不伴有食管裂孔疝的反流,发病率超过每10万人86例。很难评估反流导致轻度食管炎的程度,但很明显,反流很少导致严重程度的食管炎。严重食管炎并非总是需要手术治疗。采用保守治疗方案,并根据需要辅以探条扩张,能使风险较高的老年患者过上接近正常的寿命,且舒适度相当不错。整个系列中有53例患者接受了手术,其中一半是初次手术,另一半是在先前保守治疗后进行手术。文中讨论了手术治疗的问题。旨在预防反流的新手术方法现在使手术建议更加自由。也许相当令人惊讶的是,无论治疗是保守还是手术,严重食管炎对预期寿命的影响都很小。