Stamler R, Stamler J, Civinelli J, Pritchard D, Gosch F C, Ticho S, Restivo B, Fine D
Lancet. 1975 Dec 20;2(7947):1227-30. doi: 10.1016/s0140-6736(75)92070-x.
2 years of experience in the first phase of a large cooperative national hypertension programme yielded data indicating that a good level of patient adherence can be achieved and that satisfactory blood-pressure control can be maintained long term. For 116 participants, all employed persons, dropout in the first year was 20% but only 3% dropped out in the second year. At the second annual examination, 82% of those still in the programme had diastolic pressures under 90 mm Hg, with an average reduction of 18 mm Hg. Thus, nearly two-thirds (64%) of all patients originally enrolled were both active and with normal levels of blood-pressure after two years. Only 18% of active programme-treated patients had diastolic pressure 90 mm Hg or higher at the second anniversary in contrast with 33% of patients referred to their own doctors. In programme-treated patients, standard medication was used; diuretics effectively lowered blood-pressure in a third of patients, and diuretics plus reserpine were effective for another 20%. Special features of the programme included assistance to physicians by health counsellor therapists. Methods for achieving a high adherence-rate and satisfactory blood-pressure control probably have wider applicability.
一项大型全国性高血压合作项目第一阶段的两年经验产生的数据表明,可以实现良好的患者依从性水平,并且可以长期维持令人满意的血压控制。对于116名参与者,他们均为就业人员,第一年的退出率为20%,但第二年仅有3%退出。在第二次年度检查时,仍参与该项目的患者中有82%的舒张压低于90毫米汞柱,平均降低了18毫米汞柱。因此,在最初登记的所有患者中,近三分之二(64%)在两年后既积极参与项目且血压水平正常。在项目治疗的活跃患者中,只有18%在第二周年时舒张压达到或高于90毫米汞柱,相比之下,转诊至自己医生处治疗的患者这一比例为33%。在项目治疗的患者中,使用的是标准药物;利尿剂使三分之一的患者血压有效降低,利尿剂加利血平对另外20%的患者有效。该项目的特色包括健康咨询治疗师对医生的协助。实现高依从率和令人满意的血压控制的方法可能具有更广泛的适用性。