Adamec O, Kosutzký J, Ledec M
Vet Med (Praha). 1975 May;20(5):309-14.
After exposure of sexually immature chickens to lindan in doses of 2.5 to 25.0 mg kg-1 of feeds, the effect of the insecticide on the biological activity of estradiol was investigated. The changes in the effectiveness of estrogen, expressed by an increase of the mass of the oviduct and of the level of serum calcium, were evaluated by means of comparison of animals exposed to the insecticide with a control group that had been applied only the standard hormone dose. Proofs were obtained for the fact that the application of lindan in the quantity of the mentioned doses for 14 days caused a statistically conclusive depression of the biological effectiveness of estrogens. Compared with the control group, the stimulated mass of the oviduct of animals exposed to the insecticide was smaller by 12.7 to 17.1 p. c. and the average concentration of the serum calcium decreased by 8.0 to 27.6 p. c. The results obtained indicate that the influence of lindan already in relatively low concentrations caused significant changes in the effectiveness of exogenous estrogens.
将性未成熟的鸡以2.5至25.0毫克/千克饲料的剂量暴露于林丹后，研究了该杀虫剂对雌二醇生物活性的影响。通过将接触杀虫剂的动物与仅施用标准激素剂量的对照组进行比较，评估了以输卵管重量增加和血清钙水平升高表示的雌激素效力变化。有证据表明，以上述剂量施用林丹14天会导致雌激素生物效力出现统计学上有说服力的下降。与对照组相比，接触杀虫剂的动物输卵管受刺激后的重量减少了12.7%至17.1%，血清钙的平均浓度下降了8.0%至27.6%。所得结果表明，相对低浓度的林丹影响就已导致外源性雌激素效力发生显著变化。
