[Contact interaction between ascitic hepatoma 22a cells and solid substrate].

Quantitative analysis has shown that the cells of mouse ascites hepatoma 22a (AH-22a) possess a very low capacity for establishing steady contacts with various solid substrata (glass, carbon, collagen). This capacity considerably increased after the first formation of cell-substratum contact and was further enhanced as a result of repeated formations of such contacts (during the passaging of AH-22a cells in a monolayer culture). The effect observed was reversible since the cells of ascites tumour that developed in syngeneic mice after intraperitoneal inoculation of AH-22a cell culture rapidly lost previously acquired high capacity for adhesion to solid substrata. These modulations of cell adhesiveness are presumably related to reversible alterations in the cell surface.