Gvichiia A Sh, Rovenskiĭ Iu A
Biull Eksp Biol Med. 1980 Jun;89(6):717-8.
Quantitative analysis has shown that the cells of mouse ascites hepatoma 22a (AH-22a) possess a very low capacity for establishing steady contacts with various solid substrata (glass, carbon, collagen). This capacity considerably increased after the first formation of cell-substratum contact and was further enhanced as a result of repeated formations of such contacts (during the passaging of AH-22a cells in a monolayer culture). The effect observed was reversible since the cells of ascites tumour that developed in syngeneic mice after intraperitoneal inoculation of AH-22a cell culture rapidly lost previously acquired high capacity for adhesion to solid substrata. These modulations of cell adhesiveness are presumably related to reversible alterations in the cell surface.
定量分析表明，小鼠腹水肝癌22a（AH - 22a）细胞与各种固体基质（玻璃、碳、胶原）建立稳定接触的能力非常低。在首次形成细胞 - 基质接触后，这种能力显著增加，并由于这种接触的重复形成（在AH - 22a细胞单层培养传代过程中）而进一步增强。观察到的这种效应是可逆的，因为在腹腔接种AH - 22a细胞培养物后，同基因小鼠中产生的腹水肿瘤细胞迅速丧失了先前获得的对固体基质的高粘附能力。细胞粘附性的这些调节大概与细胞表面的可逆变化有关。
