Shikata T
Ann N Y Acad Sci. 1975 Aug 22;259:211-6. doi: 10.1111/j.1749-6632.1975.tb25415.x.
In the hepatoma cells, AFP synthesis was found to occur through ribosomes of the rough endoplasmic reticulum, since AFP was demonstrated around ribosomes of the rough endoplasmic reticulum by the peroxidase antibody technique. The secretory process was suggested to be as follows: smooth endoplasmic reticulum takes a part and the Golgi apparatus does not. Concerning the early transitory appearance of AFP in the course of hepatocarcinogenesis by 3'Me-DAB, AFP might be produced by proliferated ampulla cells, which exist between the cholangioles and liver cell cords.
在肝癌细胞中，甲胎蛋白的合成是通过粗面内质网的核糖体进行的，因为用过氧化物酶抗体技术已证明粗面内质网的核糖体周围存在甲胎蛋白。分泌过程可能如下：滑面内质网参与其中，而高尔基体不参与。关于3'-甲基二氨基联苯诱发肝癌过程中甲胎蛋白早期短暂出现的情况，甲胎蛋白可能是由存在于胆小管和肝细胞索之间的增生壶腹细胞产生的。
