Cohen P, Wittels B
J Clin Invest. 1970 Jan;49(1):119-27. doi: 10.1172/JCI106210.
The latent capacity of human platelets for oxidizing several important energy-yielding substrates has been revealed by hypoosmolaric incubation conditions. The data show that the human platelet has a considerable capacity to oxidize both glucose and long-chain fatty acids. Long-chain fatty acids appear to rank favorably with glucose as a potential energy substrate. In a number of mammalian tissues, (-)-carnitine serves to regulate the rate at which long-chain fatty acids are oxidized. Evidence was obtained which suggests that (-)-carnitine functions in a similar role in the platelet. After storage of human platelets at 4 degrees C for 24 hr, the oxidative capacity for glucose was reduced by approximately 25% and for long-chain fatty acids by almost 50%. Investigation of the component parts of the metabolic pathways indicated that a marked decrease in the capacity of the Krebs cycle could be responsible for the decrement in energy substrate oxidation.
低渗孵育条件揭示了人类血小板氧化几种重要产能底物的潜在能力。数据表明，人类血小板具有相当大的氧化葡萄糖和长链脂肪酸的能力。长链脂肪酸作为一种潜在的能量底物，似乎与葡萄糖一样具有优势。在许多哺乳动物组织中，(-)-肉碱有助于调节长链脂肪酸的氧化速率。有证据表明，(-)-肉碱在血小板中发挥类似的作用。人类血小板在4℃储存24小时后，葡萄糖的氧化能力降低了约25%，长链脂肪酸的氧化能力降低了近50%。对代谢途径组成部分的研究表明，三羧酸循环能力的显著下降可能是能量底物氧化减少的原因。
