Wheeler M, Hills L L, Laby B
Gut. 1970 May;11(5):430-7. doi: 10.1136/gut.11.5.430.
Cholelithiasis among male and female patients at the Royal Melbourne Hospital was studied, and the incidence of the disease in relation to various clinical and dietary factors is discussed. The patients are distinguished by sex and country of origin, a distinction being made between patients born in Australia and those born in southern Europe and now living in Australia. Appropriate control groups were also studied.It was shown that the incidence of cholelithiasis is higher in women than in men (3.0% as opposed to 0.7% in the Melbourne Hospital group), and higher among patients born in southern Europe than in Australia. A correlation was also established between marriage and the disease, and, in women, between having had children and the disease. The dietary investigations showed that in Australia those patients with cholelithiasis were fatter than the control patients. Equally well there seemed to be a strong family tendency to develop gallstones. No association was found between cholelithiasis and blood grouping. In the comparison of the southern European group and the Australian-born group it was shown that the former group had a higher incidence of the disease (9.3% as opposed to 2.3%), and that the overall incidence of cholelithiasis increased with age in men and was constant in women. However, when taken separately, the incidence in Australian female patients did increase with age, the higher proportion of women from southern Europe with the disease where the incidence was, in fact, evenly distributed in all age groups, accounting for this apparent constancy. It was also shown that a woman born in southern Europe increased the risk to herself of developing gallstones within two to five years of moving to Australia, and the contributory factors are discussed.
对墨尔本皇家医院男性和女性患者的胆结石病进行了研究，并讨论了该疾病发病率与各种临床和饮食因素的关系。患者按性别和原籍国区分，澳大利亚出生的患者与出生于南欧现居澳大利亚的患者有所不同。还对适当的对照组进行了研究。结果显示，胆结石病的发病率女性高于男性（墨尔本医院组中分别为3.0%和0.7%），出生于南欧的患者高于澳大利亚出生的患者。还确定了婚姻与该病之间的关联，以及女性生育与该病之间的关联。饮食调查表明，在澳大利亚，患胆结石病的患者比对照组患者更胖。同样，似乎存在患胆结石的强烈家族倾向。未发现胆结石病与血型之间存在关联。在比较南欧组和澳大利亚出生组时发现，前者的发病率较高（分别为9.3%和2.3%），而且男性胆结石病的总体发病率随年龄增长，女性则保持不变。然而，单独来看，澳大利亚女性患者的发病率确实随年龄增长，南欧女性患者患该病的比例较高，实际上发病率在所有年龄组中分布均匀，这就解释了这种明显的稳定性。还表明，出生于南欧的女性在移居澳大利亚后的两到五年内，自身患胆结石的风险增加，并对促成因素进行了讨论。
