Department of Functional Biology, University of Oviedo, C/Julián Clavería s/n, 33006 Oviedo, Asturias, Spain.
Group Diet, Microbiota and Health, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Avda. Roma s/n, 33011 Oviedo, Asturias, Spain.
Nutrients. 2018 Sep 14;10(9):1307. doi: 10.3390/nu10091307.
Recent dietary habits and lifestyle could explain the shaping of the gut microbiota composition and, in consequence, the increasing prevalence of certain pathologies. However, little attention has been paid to the influence of diet on microbiotas, other than the gut microbiota. This is important in cholelithiasis, given that changes in the production of bile acids may affect gallbladder microbial communities. Our aim was to assess the association between regular dietary intake and gallbladder microbial composition. Fourteen adults with cholelithiasis and 14 controls, sex‒age-matched and without gastrointestinal pathology, were included. Diet was assessed through a food frequency questionnaire and quantification of gallbladder microbiota sequences by Illumina 16S rRNA gene-based analysis. The cholelithiasic patients showed greater intake of potatoes and lower consumption of vegetables, non-alcoholic drinks, and sauces, which resulted in a lower intake of energy, lipids, digestible polysaccharides, folate, calcium, magnesium, vitamin C, and some phenolic compounds. Regarding the altered bile microorganisms in cholelithiasic patients, dairy product intake was negatively associated with the proportions of and and several types of fiber, phenolics, and fatty acids were linked to the abundance of , , , , and . These results support a link between diet, biliary microbiota, and cholelithiasis.
最近的饮食习惯和生活方式可能解释了肠道微生物群落的形成，从而导致某些疾病的发病率不断上升。然而，人们对饮食对微生物群的影响关注甚少，除了肠道微生物群。这在胆石症中很重要，因为胆汁酸的产生变化可能会影响胆囊微生物群落。我们的目的是评估常规饮食摄入与胆囊微生物组成之间的关联。纳入了 14 名患有胆石症的成年人和 14 名性别、年龄匹配且无胃肠道疾病的对照者。通过食物频率问卷评估饮食，通过 Illumina 16S rRNA 基因分析定量胆囊微生物序列。胆石症患者土豆摄入量较高，蔬菜、不含酒精的饮料和酱汁摄入量较低，导致能量、脂类、可消化多糖、叶酸、钙、镁、维生素 C 和一些酚类化合物的摄入量减少。关于胆石症患者胆汁微生物的改变，乳制品的摄入与 和 的比例呈负相关，而几种类型的纤维、酚类和脂肪酸与 、 、 、 和 的丰度有关。这些结果支持饮食、胆汁微生物群和胆石症之间存在联系。
