大鼠肝脏匀浆中谷胱甘肽的酶促氧化作用。
The enzymic oxidation of glutathione in rat liver homogenates.
作者信息
Jocelyn P C
出版信息
Biochem J. 1970 May;117(5):947-9. doi: 10.1042/bj1170947.
Abstract
- The aerobic oxidation of GSH and other thiols by rat liver homogenate is abolished either by previous dialysis or by removal of the proteins but is restored by a mixture of the protein-free filtrate and the dialysed homogenate. 2. The oxidation is prevented by previously heating the dialysed homogenate but not the protein-free filtrate and also by known inhibitors of xanthine oxidase. 3. A similar oxidation occurs with hypoxanthine in place of of protein-free filtrate.
摘要
- 大鼠肝脏匀浆对谷胱甘肽及其他硫醇的需氧氧化作用，可通过预先透析或去除蛋白质而被消除，但可通过无蛋白滤液与透析后匀浆的混合物得以恢复。2. 预先加热透析后的匀浆可阻止氧化，但加热无蛋白滤液则不能，已知的黄嘌呤氧化酶抑制剂也可阻止氧化。3. 用次黄嘌呤代替无蛋白滤液时会发生类似的氧化作用。
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