草地蛴螬和家蝇制剂中1,1,1-三氯-2,2-双（对氯苯基）乙烷（滴滴涕）脱氯化氢酶和谷胱甘肽S-芳基转移酶的抑制作用
The inhibition of 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) dehydrochlorinase and glutathione S-aryltransferase in grass-grub and housefly preparations.
作者信息
Balabaskaran S, Smith J N
出版信息
Biochem J. 1970 May;117(5):989-96. doi: 10.1042/bj1170989.
Abstract
The inhibition of DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane] dehydrochlorinase and glutathione S-aryltransferase by diphenylmethane and triphenylmethane derivatives was examined. Bis-(3,5-dibromo-4-hydroxyphenyl)methane and similar compounds were excellent inhibitors of both enzymes, but only DDT dehydrochlorinase was inhibited by compounds similar to bis-(N-dimethylaminophenyl)methane. Colour salts of the basic triphenylmethyl dyes were excellent inhibitors of both enzymes. All the inhibitors examined appeared to act by competition with glutathione for its binding site on the two enzymes.
摘要
研究了二苯甲烷和三苯甲烷衍生物对滴滴涕[1,1,1-三氯-2,2-双-(对氯苯基)乙烷]脱氯化氢酶和谷胱甘肽S-芳基转移酶的抑制作用。双-(3,5-二溴-4-羟基苯基)甲烷及类似化合物是这两种酶的优良抑制剂，但只有滴滴涕脱氯化氢酶能被类似于双-(N-二甲基氨基苯基)甲烷的化合物所抑制。碱性三苯甲基染料的色盐是这两种酶的优良抑制剂。所研究的所有抑制剂似乎都是通过与谷胱甘肽竞争其在这两种酶上的结合位点而发挥作用的。
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