活细胞中离子分布的研究。II. 细胞内钾离子与钠离子之间的协同相互作用。
Studies on ion distribution in living cells. II. Cooperative interaction between intracellular potassium and sodium ions.
作者信息
Ling G N, Bohr G
出版信息
Biophys J. 1970 Jun;10(6):519-38. doi: 10.1016/S0006-3495(70)86317-2.
Abstract
New steady levels of K(+) and Na(+) ion in frog sartorius muscle were reached in 72 hr at 25 degrees C in environments containing 100-mM Na(+)-ion and K(+)-ion concentrations varying from near zero to 10 mM. These steady levels follow a pattern predicted by a cooperative adsorption isotherm presented in 1964. From a total of 13 sets of experiments carried out over a five year period, the average concentration of adsorption sites is 109 mumoles/g of fresh cells. The average intrinsic equilibrium constant for the Na --> K exchange is 135, and the average free energy of nearest neighbor interaction is 0.54 kcal/mole. These values are in good agreement with those obtained by Jones and Karreman from studies on canine carotid arteries.
摘要
在25摄氏度下，将青蛙缝匠肌置于含有100 mM钠离子且钾离子浓度从接近零到10 mM变化的环境中，72小时后达到了新的钾离子和钠离子稳定水平。这些稳定水平遵循1964年提出的协同吸附等温线所预测的模式。在五年期间进行的总共13组实验中，吸附位点的平均浓度为109微摩尔/克新鲜细胞。钠钾交换的平均固有平衡常数为135，最近邻相互作用的平均自由能为0.54千卡/摩尔。这些值与琼斯和卡勒曼对犬颈动脉研究所得结果高度一致。
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