Ryder R, Lyons J P, Campbell H, Gough J
Br Med J. 1970 Aug 29;3(5721):481-7. doi: 10.1136/bmj.3.5721.481.
A correlation survey has been carried out between the pathological, physiological, and radiological findings pertaining to emphysema in 247 deceased coal miners and ex-miners, most of whom had been diagnosed as suffering from coal workers' pneumoconiosis during life. The pathological findings, which included large lung sections and detailed histology in every case, were compared with similar findings in a contrast non-mining population matched for age and sex.The results indicated that emphysema was much more common among the coal miners, both with simple and with complicated pneumoconiosis, than among the contrast group. In addition the extent of the emphysema as measured by a recognized "counting" method carried out on paper-mounted lung sections was remarkably closely related to ventilatory impairment as evidenced by the forced expiratory volume in one second.Extensive emphysema was more commonly found in those pneumoconiosis cases, both simple and complicated, showing the finer punctiform type of radiological change than in cases showing the larger micronodular and nodular opacities.
对247名已故煤矿工人和曾经的煤矿工人进行了一项相关性调查,调查内容涉及与肺气肿相关的病理、生理和放射学检查结果。这些人大多数在生前被诊断患有煤工尘肺。将包括每个病例的大肺切片和详细组织学检查结果的病理检查结果,与按年龄和性别匹配的对照非采矿人群的类似检查结果进行了比较。结果表明,无论是单纯性还是复杂性尘肺的煤矿工人,肺气肿的发生率都比对照组高得多。此外,通过在纸质肺切片上进行的一种公认的“计数”方法测量的肺气肿程度,与一秒用力呼气量所证明的通气功能损害显著密切相关。无论是单纯性还是复杂性尘肺病例,广泛肺气肿在显示更细小点状放射学改变的病例中比在显示较大微结节和结节状阴影的病例中更常见。