Jockers-Wretou E, Plessing E
J Clin Chem Clin Biochem. 1979 Nov;17(11):731-7. doi: 10.1515/cclm.1979.17.11.731.
12 cases are described, which show high serum creatine kinase-BB levels, as well as atypical creatine kinase activity band located between normally migrating creatine kinase-MM and creatine kinase-MB. It is shown that the altered properties of the serum creatine kinase-BB, namely its molecular size, heat resistance, electrophoretic mobility, but not its immunological behavior, are caused by complexing with kappa-chains of immunoglobulins G or A. The complex occurring in vivo could also be produced in vitro by using purified patients' IgG and human creatine kinase-BB.
本文描述了12例病例，这些病例显示血清肌酸激酶-BB水平升高，以及在正常迁移的肌酸激酶-MM和肌酸激酶-MB之间出现非典型的肌酸激酶活性带。结果表明，血清肌酸激酶-BB性质的改变，即其分子大小、耐热性、电泳迁移率，而非其免疫行为，是由与免疫球蛋白G或A的κ链结合所致。体内出现的这种复合物也可通过使用纯化的患者IgG和人肌酸激酶-BB在体外产生。
