甲状腺炎诱导后用环磷酰胺治疗对兔甲状腺病变的抑制作用
Suppression of thyroid lesions in rabbits by treatment with cyclophosphamide after the induction of thyroiditis.
作者信息
Nakamura R M, Weigle W O
出版信息
Clin Exp Immunol. 1970 Oct;7(4):541-50.
Abstract
An acquired immunologic unresponsive state to bovine thyroglobulin has been induced in adult rabbits following simultaneous injections of cyclophosphamide and bovine thyroglobulin. The acquired unresponsive state in some rabbits lasted at least 3 months after the last injection of bovine thyroglobulin. After induction of autoimmune thyroiditis by soluble injections of altered homologous arsanilsulphanil thyroglobulin or bovine thyroglobulin, a decrease in the incidence of thyroid lesions and the level of antithyroglobulin antibody production was observed following simultaneous injections of cyclophosphamide and native thyroglobulin.
摘要
在成年兔中，通过同时注射环磷酰胺和牛甲状腺球蛋白，诱导出了对牛甲状腺球蛋白的获得性免疫无反应状态。在一些兔子中，这种获得性无反应状态在最后一次注射牛甲状腺球蛋白后至少持续了3个月。在用改变的同源砷酰磺胺甲状腺球蛋白或牛甲状腺球蛋白的可溶性注射诱导自身免疫性甲状腺炎后，同时注射环磷酰胺和天然甲状腺球蛋白后，观察到甲状腺病变的发生率和抗甲状腺球蛋白抗体产生水平有所降低。
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THE INDUCTION OF AUTOIMMUNITY IN RABBITS FOLLOWING INJECTION OF HETEROLOGOUS OR ALTERED HOMOLOGOUS THYROGLOBULIN.注射异种或改变的同种甲状腺球蛋白后家兔自身免疫的诱导。
J Exp Med. 1965 Feb 1;121(2):289-308. doi: 10.1084/jem.121.2.289.
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