艾迪生病中的抗肾上腺细胞超敏反应。IV. 对线粒体部分的体内和体外研究。
Anti-adrenal cellular hypersensitivity in Addison's disease. IV. In vivo and in vitro investigations on the mitochondrial fraction.
作者信息
Nerup J, Andersen V, Bendixen G
出版信息
Clin Exp Immunol. 1970 May;6(5):733-9.
Nine patients with idiopathic Addison's disease and three patients with diabetes mellitus and circulating anti-adrenal antibody but without Addison's disease were studied. The organ-specific, anti-adrenal cellular hypersensitivity previously demonstrated by means of the leucocyte migration test in patients with idiopathic Addison's disease was found to be directed against the mitochondrial fraction of normal, human, foetal adrenocortical cells as well as of human, benign hyperplastic adrenal glands. The mitochondrial fraction of human, foetal liver cells did not cause inhibition of migration. In lymphocyte cultures from the patients with idiopathic Addison's disease the adrenocortical, mitochondrial fraction did not induce blast transformation. The two reactions therefore probably express different kinds of reactivity. The adrenocortical mitochondrial fraction was able to elicit intracutaneous reactions of delayed type in patients with a positive leucocyte migration test to the same antigen. This observation confirms, that inhibition of leucocyte migration indicates a state of anti-adrenal cellular hypersensitivity in patients with idiopathic Addison's disease.
对9例特发性艾迪生病患者和3例患有糖尿病且循环中存在抗肾上腺抗体但无艾迪生病的患者进行了研究。先前通过白细胞迁移试验在特发性艾迪生病患者中证实的器官特异性抗肾上腺细胞超敏反应，被发现是针对正常人胎儿肾上腺皮质细胞以及人良性增生性肾上腺的线粒体部分。人胎儿肝细胞的线粒体部分不会导致迁移抑制。在特发性艾迪生病患者的淋巴细胞培养物中，肾上腺皮质线粒体部分不会诱导母细胞转化。因此，这两种反应可能表达了不同类型的反应性。肾上腺皮质线粒体部分能够在对相同抗原白细胞迁移试验呈阳性的患者中引发迟发型皮内反应。这一观察结果证实，白细胞迁移抑制表明特发性艾迪生病患者存在抗肾上腺细胞超敏反应状态。
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