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1
Metabolism of prostaglandin E in dog kidneys.狗肾中前列腺素E的代谢
Br J Pharmacol. 1970 Oct;40(2):317-25. doi: 10.1111/j.1476-5381.1970.tb09924.x.
2
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4
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6
Identification of 6-oxo-prostaglandin E1 as a naturally occurring prostanoid generated by rat lung.鉴定6-氧代前列腺素E1为大鼠肺产生的一种天然存在的类前列腺素。
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7
Prostaglandins activation of erythropoietin production and erythroid progenitor cells.
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8
Accumulation and apparent active transport of prostaglandins by some rabbit tissues in vitro.前列腺素在体外被一些兔组织的蓄积及明显的主动转运。
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引用本文的文献

1
Effects of prostaglandin E 2 on excretion and reabsorption of sodium and fluid in rat kidneys (micropuncture studies).前列腺素E2对大鼠肾脏钠和液体排泄及重吸收的影响（微穿刺研究）
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2
Relationship between the chemical structure of prostaglandins and their vasoactivities in dogs.前列腺素的化学结构与其在犬体内血管活性之间的关系。
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3
A bilateral antidiuresis to renal artery infusion of prostaglandin E1 in dogs treated with phenylbutazone.在用保泰松治疗的犬中，肾动脉输注前列腺素E1引起双侧抗利尿作用。
J Physiol. 1978 Aug;281:1-13. doi: 10.1113/jphysiol.1978.sp012405.

本文引用的文献

1
RENOMEDULLARY VASODEPRESSOR SUBSTANCE, MEDULLIN: ISOLATION, CHEMICAL CHARACTERIZATION AND PHYSIOLOGICAL PROPERTIES.肾髓质升压物质，髓质素：分离、化学特性及生理特性
Circ Res. 1965 Jul;17:57-77. doi: 10.1161/01.res.17.1.57.
2
THE STRUCTURE OF A URINARY METABOLITE OF PROSTAGLANDIN F1-ALPHA IN THE RAT. PROSTAGLANDINS AND RELATED FACTORS 29.
J Biol Chem. 1965 Jan;240:457-61.
3
PROSTAGLANDINS AND RELATED FACTORS. 28. METABOLISM OF PROSTAGLANDIN E1 IN GUINEA PIG LUNG: THE STRUCTURES OF TWO METABOLITES.前列腺素及相关因子。28. 豚鼠肺中前列腺素E1的代谢：两种代谢产物的结构
J Biol Chem. 1964 Dec;239:4097-102.
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PROSTAGLANDINS AND RELATED FACTORS. 27. SYNTHESIS OF TRITIUM-LABELED PROSTAGLANDIN E1 AND STUDIES ON ITS DISTRIBUTION AND EXCRETION IN THE RAT.前列腺素及相关因子。27. 氚标记前列腺素E1的合成及其在大鼠体内的分布与排泄研究。
J Biol Chem. 1964 Dec;239:4091-6.
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BIOCHEMISTRY OF THE LUNG.肺的生物化学
Health Phys. 1964 Dec;10:973-9. doi: 10.1097/00004032-196412000-00016.
6
EFFECT OF PROSTAGLANDIN (PGE-1) ON THE PERMEABILITY RESPONSE OF TOAD BLADDER TO VASOPRESSIN, THEOPHYLLINE AND ADENOSINE 3',5'-MONOPHOSPHATE.前列腺素（PGE-1）对蟾蜍膀胱对血管加压素、茶碱和3',5'-单磷酸腺苷通透性反应的影响
Nature. 1965 Jan 23;205:397-8. doi: 10.1038/205397a0.
7
ISOLATION AND IDENTIFICATION OF PROSTAGLANDINS FROM HUMAN SEMINAL PLASMA. 18. PROSTAGLANDINS AND RELATED FACTORS.从人精浆中分离和鉴定前列腺素。18. 前列腺素及相关因子。
J Biol Chem. 1963 Oct;238:3229-34.
8
A vasodepressor lipid resembling prostaglandin E2 (PGE2) in the renal venous blood of hypertensive patients.在高血压患者肾静脉血中一种类似于前列腺素E2（PGE2）的血管减压脂质。
J Lab Clin Med. 1969 Sep;74(3):389-99.
9
Structures of urinary metabolites of prostaglandin F2alpha in the rat.大鼠体内前列腺素F2α的尿液代谢产物结构
Acta Chem Scand. 1969;23(4):1453-5.
10
Metabolism of prostaglandins in rat liver mitochondria.大鼠肝线粒体中前列腺素的代谢
Eur J Biochem. 1968 Oct 17;6(1):135-46. doi: 10.1111/j.1432-1033.1968.tb00430.x.

狗肾中前列腺素E的代谢

Metabolism of prostaglandin E in dog kidneys.

作者信息

Nakano J

出版信息

Br J Pharmacol. 1970 Oct;40(2):317-25. doi: 10.1111/j.1476-5381.1970.tb09924.x.

DOI:10.1111/j.1476-5381.1970.tb09924.x
PMID:5492900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1702883/
Abstract
  1. The biotransformation of prostaglandin E(1) (PGE(1)) was studied in the isolated, perfused dog kidneys.2. An average 43% of PGE(1) was converted into the less polar metabolite I by a single passage through the kidney. As the re-circulation of the perfusate continued, PGE(1) was converted not only into metabolite I but also the least polar metabolite II. The velocity of the conversion of PGE(1) into metabolite I was significantly greater than that into metabolite II. Usually, six passages elapsed before maximum degradation of PGE(1) occurred.3. Further separation with silicic acid column chromatography and gas-liquid chromatography showed that metabolite II consists of two individual metabolites, metabolite IIa and metabolite IIb.4. The present study indicates that the kidney biotransforms PGE(1) rather rapidly into three metabolites which are less polar than PGE(1).
摘要

  1. 在离体灌注的犬肾中研究了前列腺素E(1)（PGE(1)）的生物转化。

  2. PGE(1)单次通过肾脏时，平均有43%转化为极性较小的代谢物I。随着灌注液再循环的持续，PGE(1)不仅转化为代谢物I，还转化为极性最小的代谢物II。PGE(1)转化为代谢物I的速度明显快于转化为代谢物II的速度。通常，在PGE(1)发生最大程度降解之前经过六次循环。

  3. 用硅酸柱色谱和气相色谱进一步分离表明，代谢物II由两种单独的代谢物组成，即代谢物IIa和代谢物IIb。

  4. 本研究表明，肾脏能将PGE(1)相当迅速地转化为三种比PGE(1)极性更小的代谢物。