Bragt P C, Schenkelaars E P, Bonta I L
Prostaglandins Med. 1979 Jan;2(1):51-61. doi: 10.1016/s0161-4630(79)80008-7.
During kaolin-induced granuloma pouch inflammation in the rat the concentration of malondialdehyde (MDA) in the exudate, measured by the 2-thiobarbiturate method, steadily increased and this increase was correlated with the increase in granuloma weight. There was a complete lack of correlation between the concentrations of MDA and prostaglandin (PG)-like material in the inflammatory exudate. Whereas the concentration of PGs reached a maximum 1 day after the induction of inflammation and returned to control levels on day 4, the MDA concentration continuously increased from the initiation of inflammation up to day 16. During granuloma development the concentration of MDA in the plasma reached a maximum on day 2 in parallel with the concentration in the liver, then both plasma and liver MDA decreased to levels observed in control rats. Between day 2 and 8 of the inflammatory process homogenates of livers from inflamed rats showed an increased formation of MDA on incubation, the amount formed being maximal on day 4. The results of the present study are discussed in view of a possible involvement of lipid peroxidation in inflammation.
在大鼠高岭土诱导的肉芽肿袋炎症过程中，通过2-硫代巴比妥酸法测定，渗出液中丙二醛（MDA）的浓度稳步增加，且这种增加与肉芽肿重量的增加相关。炎症渗出液中MDA浓度与前列腺素（PG）样物质浓度之间完全没有相关性。PGs浓度在炎症诱导后1天达到最大值，并在第4天恢复到对照水平，而MDA浓度从炎症开始到第16天持续增加。在肉芽肿形成过程中，血浆中MDA浓度在第2天达到最大值，与肝脏中的浓度平行，然后血浆和肝脏中的MDA均降至对照大鼠中观察到的水平。在炎症过程的第2天至第8天之间，发炎大鼠肝脏的匀浆在孵育时显示MDA形成增加，形成量在第4天最大。鉴于脂质过氧化可能参与炎症反应，对本研究结果进行了讨论。
