Burton J L, Shuster S
Acta Derm Venereol. 1975;55(6):493-6.
Severe extensive alopecia areata (totalis) was treated with prednisolone as a single 2 g dose i.v. (22 patients) or 0.5 g daily for 5 days orally (13 patients). Four of the patients responded well, 12 had a poor response and 19 had no response. There was a relapse in some at about 6 months, which could be arrested by a further single i.v. dose, but the risks of this form of therapy are unclear and it cannot be recommended for general use. The clinical response to a single dose of corticosteroid implies, however, that there may be a 'switch' mechanism in certain auto-immune diseases, with an all-or-none response.
严重广泛性斑秃（全秃）患者接受了泼尼松龙治疗，静脉注射单次剂量2g（22例患者）或口服每日0.5g，共5天（13例患者）。4例患者反应良好，12例反应较差，19例无反应。部分患者在约6个月时复发，可通过再次静脉注射单次剂量阻止，但这种治疗方式的风险尚不清楚，不建议普遍使用。然而，对单剂量皮质类固醇的临床反应表明，某些自身免疫性疾病可能存在一种“开关”机制，呈现全或无的反应。
